ID   A0A2Y9IHY0_ENHLU        Unreviewed;       964 AA.
AC   A0A2Y9IHY0;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Ankyrin repeat and LEM domain-containing protein 2 {ECO:0000313|RefSeq:XP_022347866.1};
GN   Name=LOC111139775 {ECO:0000313|RefSeq:XP_022347866.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022347866.1};
RN   [1] {ECO:0000313|RefSeq:XP_022347866.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022347866.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022347866.1; XM_022492158.1.
DR   AlphaFoldDB; A0A2Y9IHY0; -.
DR   STRING; 391180.A0A2Y9IHY0; -.
DR   KEGG; elk:111139775; -.
DR   OrthoDB; 5402020at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   CDD; cd12944; LEM_ANKL2; 1.
DR   Gene3D; 1.10.720.40; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011015; LEM/LEM-like_dom_sf.
DR   InterPro; IPR035006; LEM_ANKL2.
DR   InterPro; IPR003887; LEM_dom.
DR   InterPro; IPR011320; RNase_H1_N.
DR   InterPro; IPR037056; RNase_H1_N_sf.
DR   PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR12349:SF4; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF01693; Cauli_VI; 1.
DR   Pfam; PF03020; LEM; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF63451; LEM domain; 1.
DR   PROSITE; PS50954; LEM; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          71..115
FT                   /note="LEM"
FT                   /evidence="ECO:0000259|PROSITE:PS50954"
FT   REGION          39..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          703..728
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          757..800
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          892..949
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   964 AA;  106326 MW;  B63BFC1F93D61DE0 CRC64;
     MLWPRLAAAE WAPLVWELLG ASVLLIAVRW LVRRLEKRPR GLGRSGPPAP PPGAATNSAL
     DPGEMTMDAI LARLKLLNPD DLREEIVKAG LKCGPITSTT RFIFEKKLAQ ALLERGRTLP
     SHPPGCDTSG ATALSRDAQK MSKSAVESQA EQVGLSEDRD FGYSVGLNPP EEDVVTSKTC
     SVPFSATTGV SGHKAVARAS AEPPLYYGVC PAYEDTPARN ERIHVYEDRK EALQAVKMIK
     GSRFKAFSSR EDAEKFARGI CDYFPSPSKA SSPLSPVKIT SVFSGGVKDA AYSSESETIN
     RERANSYKTP RTQDLTAKLR KAVEKGEEDL FSDLTWSNPR YLIGSGDNPT IVQEGCRYNV
     MHVAAKENQA SICQLTLETL ENPEFMRLMY PDDEPHMLQQ RICYIVDLYL NTPDKAGYDT
     PLHFACKFGN ADVVNVLSSH PLIVKNPRNK YDKTPEDVIC ERSRNKSVEL KERIREYLQG
     HYYVPLLRAE DTSSPVIGEL WSSDQTTETS HIGHGGGGPR DPVLTLRAFA GPLSPSKAED
     FRKLWKTPPR EKAGFFHNVR KTDPERGMER VGRELARELG YPWVEYWDFL GCFVDLSSQE
     GLQKLEEYLS QQEAGKKSPQ DLGENEACRQ ENSSAFGRAR KCSNSISVRA FLDEDDDLSL
     EEIKNRQNTA RNNTQPTVST FGDSKCDILP LEQETSLIEA STLTSPHGSK NGFCGPLSGS
     RTPGRKRLEA PGAGEALISP VSGLTVEFDK LQLQDLGSNF SKTPNKSRKT RDKKSFTSRA
     DAVESDWLEP PAADTLTENQ TRTESEMSAK MSKIHLGPDT PVPQVQQNCG SMSSEPSGVP
     TTKEPVERLF LFGEEPSKLD RDVLAALECT EVDPQRYPAV HRWRSAVLRY SPTDRQSWPS
     PALKGKLESR QPDVGCAHSC SPGRSPGKPG PAPHSPGLGS PGRYSPARGS HLRRMAHLAQ
     LTAL
//