ID   A0A2Y9IK48_ENHLU        Unreviewed;       447 AA.
AC   A0A2Y9IK48;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Docking protein 3 isoform X1 {ECO:0000313|RefSeq:XP_022349032.1};
GN   Name=LOC111141009 {ECO:0000313|RefSeq:XP_022349032.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022349032.1};
RN   [1] {ECO:0000313|RefSeq:XP_022349032.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022349032.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DOK family. Type A subfamily.
CC       {ECO:0000256|ARBA:ARBA00010955}.
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DR   RefSeq; XP_022349032.1; XM_022493324.1.
DR   AlphaFoldDB; A0A2Y9IK48; -.
DR   STRING; 391180.A0A2Y9IK48; -.
DR   KEGG; elk:111141009; -.
DR   OrthoDB; 2996885at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   CDD; cd14676; PH_DOK1_2_3; 1.
DR   CDD; cd01203; PTB_DOK1_DOK2_DOK3; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR037751; Dok1/2/3_PTB.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR21258:SF42; DOCKING PROTEIN 3; 1.
DR   PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR   Pfam; PF02174; IRS; 1.
DR   SMART; SM01244; IRS; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00310; PTBI; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS51064; IRS_PTB; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          157..261
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000259|PROSITE:PS51064"
FT   REGION          259..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          409..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..447
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   447 AA;  48859 MW;  08693D7D980EF414 CRC64;
     MEPLETPVKD GILYQQHVKF GKKSWRKVWG LLYAGSPSGV ARLESWEVRE GGLGPAGDRP
     TGPSRRGERR VIRLADCVSV LPADGESCPK DTSAFLLTTT ERSHLLAAQH RQEWMGPICQ
     LAFQGTGECS SGPGEMEASK RGLVPMEENS IYSSWQEAGE FPVVVQRTEA ATRCQLKGPY
     LLVLGQDTIQ LREASSPQAL YTWPYRFLRK FGSDKDVFSF EAGRRCDSGE GLFAFSSPRA
     PDLCRAVTAA IARQRERLPE LAGPRPCPLP RATSLPSLDP PGELREVPLG LEPPSSRRAL
     LADPGPQSLP PQLNPVPRDE PVSGLYASVC KRASGPPANA EHLYENLCML EAGPVLPRDK
     DPGQEDSSRR SPLASPIYHN SEDLGWPGPT HDSSLEAQYR RLLELELGDS DETASSGRPS
     AHTGFKAKLV TLLSRERKKG PAPCDRP
//