ID A0A2Y9IK65_ENHLU Unreviewed; 1078 AA.
AC A0A2Y9IK65;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Importin-4 isoform X2 {ECO:0000313|RefSeq:XP_022348631.1};
GN Name=LOC111140717 {ECO:0000313|RefSeq:XP_022348631.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022348631.1};
RN [1] {ECO:0000313|RefSeq:XP_022348631.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022348631.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_022348631.1; XM_022492923.1.
DR AlphaFoldDB; A0A2Y9IK65; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR Pfam; PF13513; HEAT_EZ; 2.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 24..90
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REPEAT 391..431
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 897..933
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 639..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1078 AA; 117834 MW; 342E39AE85C5F3EC CRC64;
MEPGGLEQIL RELLLPDTER IRRATEQLQT ALRDPAALPA LCDLLASAVD PQIRQFAAVL
TRRRLSTSWR RLAAEHRESL KSLVLTAFQR ETEHSVSLSL AQLSGTIFRK EGLEAWPQLM
QLLQHSTHSP HIPEREMGLL LLSVVVTSRP EAFQPHHREL LRLLNETLGE VGSPGLLFYS
LRTLTTMAPY LGTDDVPLAR MLVPKLIVAV QTLISADEAK ACEAVEALDE LLESEVPIIT
SHLSEVLTFC LEVARNVALG DAIRVRILCC LSFLVKVKSK ALLKNRLLPP LLHTLFPIMA
AEPALGQLDP EDQDSEEEEL ESGLVGETPK HFAVQVVDML ALHLPPEKLC PLLMPVLEEA
LRSERPYQRK AGLLVLAVLS DGAGDHIRQR LLPPLLQIVC KGLEDPSQVV RNAALFALGQ
FSENLQPHIS SYAGEVMPLL LAYLKSVPPG HTNHLAKACY ALENFVENLG PKVQPYLPEL
MECMLQPLRN PSSPRAKELA VSALGAIATA AQASLLPYFP TIMEHLREFL LTGREDLQPV
QIQSLETLGV LARAVGEPMR PLAEECCQLG LGLCDQVDDP DLRRCTYSLF AALSGLMGEG
LAPHLPQITT LMLLSLRSTE GIVPQYDGSS SFLLFDDESD GEEEEELMDK DEEEEDDSEI
SGYSVENAFF DEKEDTCAAL GEISVNTSVA FLPYMESVFE EVFKLLECPH LNVRKAAHEA
LGQFCCALHK ACQSCPSEPN TAALQVALAR VVPSYMQAVS SERERQVVMA VLEALTGVLR
SCGPLVLQPP GRLAELCGML KAVLQRKTAC QDPEEEEEEE QAEYDAMLLE HAGEAIPALA
AAAGGDAFAP FFASFLPLLL CKTKQGCTVA EKSFAVGTLA ESIQGLGGAS AQFVSRLLPV
LLSTAREADP EVRSNAVFGL GVLAEHGGRP AQEYFPKLLG LLLPLLARER HDRVRDNICG
ALARLLMASP TRKPEPQVLA ALLHALPLKE DLEEWVTIGH LFSFLYQSSP DQVVDVAPEL
LRICSLILAE NTIPPDTKAT LLLLLTFLAQ QHTDSFHSAL GSLPGDKAQE LQAALGLT
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