ID A0A2Y9IKW0_ENHLU Unreviewed; 797 AA.
AC A0A2Y9IKW0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=E3 ubiquitin-protein ligase Jade-2 isoform X3 {ECO:0000313|RefSeq:XP_022349307.1};
GN Name=LOC111141195 {ECO:0000313|RefSeq:XP_022349307.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022349307.1};
RN [1] {ECO:0000313|RefSeq:XP_022349307.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022349307.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_022349307.1; XM_022493599.1.
DR AlphaFoldDB; A0A2Y9IKW0; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15705; ePHD_JADE2; 1.
DR CDD; cd15680; PHD_JADE2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR039549; JADE2_ePHD.
DR InterPro; IPR039548; JADE2_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF84; E3 UBIQUITIN-PROTEIN LIGASE JADE-2; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 211..261
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 263..377
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 34..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..688
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 88321 MW; 45D56349CEF5154F CRC64;
MEEKRRKYSI SSDNSDTTDS KAFHLGLLQG KHLSHATSAS RCSKLPSSTK SGWPRQNEKK
PSEVFRTDLI TAMKIPDSCQ LSPDDYYILA DPWRQEWEKG VQVPAGAEAI PEPVVRILPP
LEGPPTQVSP SCSELGEGSQ PDWPGGSRYD LDEIDAYWLE LINSELKEME RPELDELTLE
RVLEELETLC HQNMVRAIET QEGLGIEYDE DVVCDVCRSP EGEDGNEMVF CDKCNVCVHQ
ACYGILKVPT GSWLCRTCAL GVQPKCLLCP KRGGALKPTR SGTKWVHVSC ALWIPEVSIG
CPEKMEPITK ISHIPASRWA LSCNLCKECT GTCIQCSMPS CVTAFHVTCA FDHGLEMRTI
LADNDEVKFK SFCQEHSDGG PRGEPTSDPA EPSPAGEDLE KVTVRKQRLQ QLEEDFYELV
EPAEVAERLE LAEALVDFIY QYWKLKRKAN ANQPLLTPKT DEVDNLAQQE QDVLYRRLKL
FTHLRQDLER VRNLCYMVTR RERTKHAICK LQEQIFHLQM KLIEQDLCRG LSTSFPIDGT
FFNSWLAQSV QITAENMAMS EWSLNHGHRE DPAPGLLSEE LLQDEETLLS FMRDPSLRPG
DPARKARGRT RLPAKKKPPQ DGPGSRTIPD KSPKKPWGQD AGSGKGGQGP VARKATRRTP
SHLPSSPAAG DCPIPAAPES PPLVPETPDE AVPMAADSNV QVPGPPVSPK PLGRLRLPRE
NKGTRRSPGA RPDAATGPPS AVAERPKVSL HFDTETDGYF SDGEMSDSDV EAEDSGVQQA
PREAGAEEVV RMGVLAS
//