ID A0A2Y9IKW3_ENHLU Unreviewed; 1035 AA.
AC A0A2Y9IKW3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 3 {ECO:0000256|ARBA:ARBA00040040};
GN Name=LOC111139817 {ECO:0000313|RefSeq:XP_022347944.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022347944.1};
RN [1] {ECO:0000313|RefSeq:XP_022347944.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022347944.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center {ECO:0000256|ARBA:ARBA00004267}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004394}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR RefSeq; XP_022347944.1; XM_022492236.1.
DR AlphaFoldDB; A0A2Y9IKW3; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd00116; LRR_RI; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF19; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 5.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 9.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..93
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 215..531
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1035 AA; 118757 MW; F58438FFF83C13B7 CRC64;
MNMASVRCKL AHYLEDLEDA DFKKFKMHLQ DYPSQKGCRP LPRSQTEKAD HMDLATLMID
FNGEEKAWAM AVWIFAAINR RDLYEKAKRD APECDNVHVV CREESLEEEW MGLLGYLTRI
SICKKRKDYC KKYKKHVRSR FQCIKDRNAR LGESVNLNKR YTRLRLVKEH QSQQEREHEL
LAIGRTSART LDSPVSSLNM ELLFEPDDQH SEPVHTVVFQ GAAGIGKTIL ARKIMLDWAS
EKIYQDRFDY LFYIHCREVS LGTRRSLGDL IVSCCPDPNP PIYKIVSKPS RILFLMDGFD
ELQGAFDEHT ETLCTNWQKV ERGDILLSSL IRKRLLPEAS LLITTRPVAL EKLQHLLDRP
RHVEILGFSE AKRKEYFFKY FSDEQQATEA FRLIQENEIL FTMCFIPLVC WIVCTGLKQQ
MDSGKSLAQT SKTTTAVYVF FLSSLLQSRG ENQKHQVSAN IWGLCSLAAD GIWNQKILFE
ECDLRNHGLQ RADVSAFLRM NLFQKEVDCE KFYSFIHMTF QEFFAAMYYL LEEEEQGRLR
NLPWRSSKLP NRDVTVLLEN YGKFEKGYLI FVVRFLFGLV NQERTSYLEK KLSCKISQHI
RLELLKWIKE KAKAKNLQIQ PSQLELFYCL YEMQEEDFVQ KAMGHFPKIE ISLSTRMDHV
VSSFCIENCH NVESLSLRLL HNSSKEEEEE EEEEGEMQHS EVDHCVRLDP HAACTHRLVN
CHVTLSLWQG LFSVLSTNSL NLTELNLSDN ALGDPGVQVL CEMLQRPGCN IRRLWLGRCC
LSHHCCFNIS SVLSSNQKLM ELDLSHNALG DFGIRLLCVG LRHLFCNLKK LWLVSCCLTS
ACCEDLASVL STNQSLTRLY LGENALGDAG VGILCEKAKH PQCKLQKLGL MNSGLTSGCC
SALSSVLSTN QKLTHLYLRG NALGDTGVKL LCEGLLHPNC KLQILELDGC SLTSHCCWDL
STLLTSNKSL RELSLGSNDL GDLGVMLLCE VLKQQGCLLK SLKLCEMYFN YDTKCALEAL
QEEKPELSIV FEPFW
//
