ID A0A2Y9ILU3_ENHLU Unreviewed; 874 AA.
AC A0A2Y9ILU3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Rho GTPase-activating protein 4 isoform X3 {ECO:0000313|RefSeq:XP_022347010.1};
GN Name=LOC111139146 {ECO:0000313|RefSeq:XP_022347010.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022347010.1};
RN [1] {ECO:0000313|RefSeq:XP_022347010.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022347010.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022347010.1; XM_022491302.1.
DR AlphaFoldDB; A0A2Y9ILU3; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07656; F-BAR_srGAP; 1.
DR CDD; cd11956; SH3_srGAP4; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035678; srGAP4_SH3.
DR PANTHER; PTHR14166:SF16; RHO GTPASE-ACTIVATING PROTEIN 4; 1.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 19..318
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 508..696
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 747..806
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 186..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..874
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 97028 MW; 3F02E505C55F2FEC CRC64;
MAAHGKLRRE RGLQAEYEAQ VKEMRWQLGE QLRCLELQGE LRRELLQELA EFLRRRAEVE
LEYSRGLDKL AERFSGRGGR LGGSSREHQS FRKEPSLLSP LHCWAVLLQQ TRQQSRESAA
LGEVLAGPLA QRLSHIAEDV GRLVKKSKDL EQQLQEELLE VVSELQTAKK TYQLYHTESM
NAEAKLREAE RQEEKRAGRS ATGAPATATD TGPLRKSSLK KGGRLVEKRQ AKFLEHKLKC
TKARNEYLLS LASVNAAVSN YYLHDVVDLM DCCDTGFHIA LAQLLRSYVA AESRAQVSHM
QGLGSLEEAV EALDPSGDKA KVLEVHAVAF CPPQRFDYHP HEGDEVAEIR LEMELRDEIL
PRAQNIQSRL DRQTIETEEV SKTLKATLQV LLEAAAAEDG DALDSLQASP STESLKSTSS
DAGARQAGRR RGQQQETETF YITKLQEYLS GRSVLAKLQA KHEKLQEAIQ RGDKDEQDVS
WAQYTQRKQQ KSRRPRPSSQ YNQKLFGGDM EKFIQSSGQP VPLVVESCVR FINLNGLQHE
GIFRVSGAQP RVSEIRDAFE RGEDPLVEGC TPHDLDAVAG VLKLYFRSLD PPLFPPDLFG
ELLASAELEA VAERVEHVGR LLTQLPAPAL VVLRYLFTFL NHLAQYSDEN MMDPYNLAVC
FGPTLLPVPA GQDPVALQGR VNQLVQTLIV QPSRVFPPVA VLPGPTYEKC MAPPSSSCLG
DAQLEGLAGE NEPELEAGTT AQEDDLEGVV EAVACFAYTG RTAQELSFQR GDVLRLHERA
SGDWWRGECA GTRGLIPHKY ITLPGSAEKH TVAQGPQAAG ELVSSPEVLL AMEFVHRPWP
RPWTPCLRSS WERPPPAKGL GRRPPAPLAP GPAA
//
