ID   A0A2Y9INR9_ENHLU        Unreviewed;      1507 AA.
AC   A0A2Y9INR9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Gem-associated protein 5 isoform X4 {ECO:0000313|RefSeq:XP_022348994.1};
GN   Name=LOC111140990 {ECO:0000313|RefSeq:XP_022348994.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022348994.1};
RN   [1] {ECO:0000313|RefSeq:XP_022348994.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022348994.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022348994.1; XM_022493286.1.
DR   Proteomes; UP000248482; Unplaced.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR024977; Apc4-like_WD40_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR46362; GEM-ASSOCIATED PROTEIN 5; 1.
DR   PANTHER; PTHR46362:SF1; GEM-ASSOCIATED PROTEIN 5; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 2.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 13.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          60..104
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          240..263
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          393..478
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
FT   DOMAIN          539..587
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
FT   REPEAT          634..667
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          716..799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1310..1344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1386..1428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..734
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        749..768
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1310..1325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1326..1344
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1386..1424
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1507 AA;  168352 MW;  47F80816FAD64187 CRC64;
     MGQDPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPNAGAIPG TPPFRVLGEL
     VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKA VVTEHALHQH TISALHWSPQ
     VKDLIVSGDE KGVVFCYWLN RNDSQHHFIE PRTIFCLTCS PHHEDLVAIG YKDGIVVIID
     ISKKGEVIHR LRGHDDEIHS IAWCPLPGED CLSINQEENS EPEIPNGKVI EQTPVTKGCY
     LATGSKDQTI RIWSCSRGRG VMILKLPFLK RRGGGIDPTV KERLWLTLHW PKDQPTQLVS
     SCFGGELLLW DLTQSWRRKY TLFSASSEGQ NHSRIVFNLC PLQTEDDKQL LLSTSMDRDV
     KCWDMATLEC CWTLPSLGGF AYSLAFSPVD MGCLAIGVGD GMIRVWNTLS IKNNYDVKNF
     WQGVKSKVTA LCWHPAKEGC LAFGTDDGKV GLYDTYSNKP PQISSTYHKK TVYTLAWGPP
     LPPISLGGEG DRPSLTLYSC GGEGIVLQHN PWKLGGEAYD INKLIRDTNS IKYKLPVHTE
     ISWKADGKIM ALGNEDGSIE IFQVPNLKLI CTIQQHHKLV NTISWHHEHG SQPELSYLMA
     SGSNNAIIYV HNLKTVIESN PESPVTITEP YRTLSGHTAK ITSVAWSPHH DGRLVSASYD
     GTAQVWDTLR EEPLCNFRGH RGRLLCVAWS PLDPDCIYSG ADDFCVYKWL TSMQEHSRPP
     QGKKSIELEK KRLSQPKPKP KKKKKPTSRA PVKQEVYDGN EDESIRESSG PVENGVSDQE
     GEEEAREPEF PSGVASVASR EPVTCAPVSL GFEKSKVTVN NKVTLLKKEP PKEKPESLTK
     KRKARSMLPL TTSLDHRSKE ELHQDCLVLA TAKHSKELNE EVSADLEERF HLGLFTDRGA
     LYRMIEVEGK GHLENGHPEL FHQLMLWKGD LKGVLQTAAE RGELTDSLVA MAPVAGYHVW
     LWAVEAFAKQ LCFQDQYVKA ASHLLSIHKV YEAVELLKSN HFYREAIAVA KARLRPEDPI
     LKDLYLTWGA ILEKDGHYAV AAKCYLGAAS AYDAAKVLSK KGDAASLKTA AELASIVGEN
     DLSSSLALRC AQELLLARNW VGAQEALKLH ESLKGQRLVF CLLELLSKHL EERQLLEAKS
     SSYNAWATGT AGPFVERVTA VWKNTFSLES PEQYQAALQQ LQSIKYPSAT NNTPSKQLLL
     HICHDLTLAV LSQQVASWDA AVEALLRAVV RSYDSGNFTI MQEVHSAFLP EGCDHLKHKL
     GEPQSPITPA FKSLEAFFIY GHLYEFWWSL SRHCPKSSVW VRAAHRRTTS VEQSQQINNA
     TPEETDSRDS QPEPNRPPEL DVRLTEESKQ MLITCKELFS EKHASLQNSQ RTVAEVQETL
     AEMIRQHQKS QVCKSTTNGP DKNESEQAAE QSLSSPQNEC KEEKNQPLSL PELTKRLTEA
     NEKIAKFPES VKIWPFPDVL ECCLILLHIG SQCPGSVTQD MQQQAQELLQ KYGNTKVYKR
     YCETFCT
//