ID A0A2Y9INW9_ENHLU Unreviewed; 499 AA.
AC A0A2Y9INW9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Growth/differentiation factor 5 {ECO:0000313|RefSeq:XP_022350417.1};
GN Name=LOC111141865 {ECO:0000313|RefSeq:XP_022350417.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022350417.1};
RN [1] {ECO:0000313|RefSeq:XP_022350417.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022350417.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_022350417.1; XM_022494709.1.
DR AlphaFoldDB; A0A2Y9INW9; -.
DR STRING; 391180.A0A2Y9INW9; -.
DR KEGG; elk:111141865; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19399; TGF_beta_GDF5; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF44; GROWTH_DIFFERENTIATION FACTOR 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..499
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016089254"
FT DOMAIN 376..499
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 29..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 55238 MW; FC94CAD1D964D0A4 CRC64;
MRLPKLLTFL LWHLAWLDLE IICTVLGAPD LGQRPQGARP GLAKAEAKER PPPARSIFRP
GGHSYGGGAA NARAKGGTGQ TGGLTQPKKD ELKKPPPRSG GPEPKPGRPP QTRQAATRTV
TPKGQLPGGK APPKAGSVPS PFLLKKARET RPPQEPEEPF RPPPITPHEY MLSLYRTLSD
ADRKGGNSSV KLEAGLANTI TSFIDKGQDD RGPVVRKQRY VFDISALEKD GLLGAELRIL
RKKPSDTAKP VAPGIGRAAQ LKLSSCPSGR QPAALLDVRS VPGLDGSGWE VFDIWKLFRN
FKNSAQLCLE LEAWERGRAV DLRGLGFDRA ARQVHEKALF LVFGRTKKRD LFFNEIKARS
GQDDKTVYEY LFSQRRKRRA PLATRQGKRP TKNPKARCSR KALHVNFKDM GWDDWIIAPL
EYEAFHCEGL CEFPLRSHLE PTNHAVIQTL MNSMDPESTP PTCCVPTRLS PISILFIDSA
NNVVYKQYED MVVESCGCR
//
