ID A0A2Y9IQL0_ENHLU Unreviewed; 958 AA.
AC A0A2Y9IQL0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Zinc fingers and homeoboxes protein 3 {ECO:0000313|RefSeq:XP_022349629.1};
GN Name=LOC111141401 {ECO:0000313|RefSeq:XP_022349629.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022349629.1};
RN [1] {ECO:0000313|RefSeq:XP_022349629.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022349629.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the ZHX family. {ECO:0000256|ARBA:ARBA00007440}.
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DR RefSeq; XP_022349629.1; XM_022493921.1.
DR AlphaFoldDB; A0A2Y9IQL0; -.
DR STRING; 391180.A0A2Y9IQL0; -.
DR KEGG; elk:111141401; -.
DR OrthoDB; 5350395at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 4.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 5.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR024578; Homez_homeobox_dom.
DR InterPro; IPR041057; ZHX_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR15467:SF6; ZINC FINGERS AND HOMEOBOXES PROTEIN 3; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF00046; Homeodomain; 3.
DR Pfam; PF11569; Homez; 1.
DR Pfam; PF18387; zf_C2H2_ZHX; 1.
DR SMART; SM00389; HOX; 4.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 5.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 320..363
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 503..553
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 624..672
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 776..826
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 322..364
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 505..554
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 626..673
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 778..827
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 22..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 103340 MW; E1B1AFD68926E04E CRC64;
MASKRKSTTP CMIPVKTVVL QDASAEAQPA EALPEGPQQE LPPEAPASSS EATPTPSSTD
GPALANGHRG TLDGYSYSCK YCDFRSQDIT QFVGHMNSEH PDFNKDPTFV CTECSFLAKT
PEGLSLHNAK CHLGEASFVW NVAKPDNHVV VEQSVPESTC APDTPSEPNA EGTDGQAEII
ITKTPIMKIM KGKAEAKKIH TLKENMPSQP VGDTALPNPQ AGETEAKEGD HPFVNGAVPV
SQPAAGSAKG PHAANGPLLG AVPVLPAGIA QFLPLQQPPP VHAQHHGHQP LPTSKSLPKV
MIPLSSIPTY NAAMDSNSFL KNSFHKFPYP TKAELCYLTV VTKYPEEQLK IWFTAQRLKQ
GISWSPEEIE DARKKMFNTV IQSVPQPTIT VLNTPLVANA GGVQHLIQAA LPGHVVGQPE
GTAGGLLVTQ PLMANGLQAP GSSLPPAVTS VPKQPPAAPI NTVCSNTASA VKVVNAAQSL
LTACPSITSQ AFLDASIYKN KKSHEQLSAL KGSFCRNQFP GQSEVEHLTK VTGLSTREVR
KWFSDRRYHC RNLKGSRAVL PGDPGAVVID PGPEAPCSPA VAKAPEVPCV PPAATLAAPP
SARRQAWHQT PDFTPTKYKE RAPEQLRALE SSFAQNPLPP DEELDRLRTE TKMTRREIDS
WFSERRKRVS AEDPRRADEG PGPDEEAVAA AEDEAGEGEL VGDLRVPGED GSLEGLSSHA
LAERKVSPIK INLKNLRVTE ANSRSELPGP GACEPEEEGP GKPAEQPPGK ASCKKTAPQR
HLLRRLFVQT RWPSTQDYDA ITAQTGLPRP EVVRWFGDSR YALKNGQLKW YEDYKRGNFP
PGLLVIAPGN RELLQDYYGT HKTLREEDLQ SLCDQTQMSS QQVKQWFAEK MGEDTRAVAD
TGGEDQGARE PAAVHKGTGD AYAEVSENSE SWEPGAPEAS SEPFDTRSPQ AGLQLETD
//
