ID A0A2Y9IRV6_ENHLU Unreviewed; 813 AA.
AC A0A2Y9IRV6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=LOC111141631 {ECO:0000313|RefSeq:XP_022350059.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022350059.1};
RN [1] {ECO:0000313|RefSeq:XP_022350059.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022350059.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR RefSeq; XP_022350059.1; XM_022494351.1.
DR AlphaFoldDB; A0A2Y9IRV6; -.
DR STRING; 391180.A0A2Y9IRV6; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF100; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 222..243
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 306..330
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 342..368
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 388..409
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 462..483
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 503..523
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 657..681
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 183..755
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 576..633
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 85801 MW; AAD9196B94169A94 CRC64;
MQVGQKVSPM RLGSGQRSHR LPRGTRHRTR RVLSEMLVWS SVHISFLTRS SSRRTNQPLD
YHREVSVAAP CAPQVEMPQH SMGDKPQLVF PSQPSAADGG CGHGPPSGLA SLGSPRSHGT
LGPAMRSPLD ACSQPLCPPQ AEKHGPRAPP EMCYVAARPQ SVACGWGAFA PRCLQAFNTP
RGFLLFLCAA AFLQGMTVNG FVNTVVTSIE RRFDLHSHQS GLIASCYDVA ACLCLTFVSY
FGGGGHKPRW LGWGVLVLGA GSLLFALPHF TAGTYEAEMA EGVGTCQANR SVVCRDRASG
LSGYRLVFML GQFLHGVGAT PLYTLGVTYL DENVKSSYSP VYIAVFYTAA ILGPAAGYLI
GGALLNIYTE IGRQTELTTE NPLWVGAWWV GFLGAGAAAF LTAIPILGYP RQLPGSQRYL
VMRVSETQQL KDSGHKAASN PDFGKTIRDL PLSIWLLLKN PAFVLLCLAG ATEATLVAGM
STFGPKFLES QLSLSASEAA TLFGYLVVPA GGGGTFLGGF LVNKCRLRGA GVVKLCALCT
LTSLLATFVF FVQCPSTPMA GVTANYNGSP LPEGRLELTA ACNAPCACRP EHYSPVCGSN
GLTYYSPCHA GCPGEAAPGA DGRKAYRGCS CVPQEFSSGS GHATAGKCTS TCQRKPLLLV
FIFAVIIFTF LSSIPALTAT LRCVCDRQRS FALGIQWIVV RTLGGIPGPI AFGWVIDKAC
LLWQDQCGQQ GSCFVYQNSA MSRYMLITGL VYKVREAAAG PRGPEGAPES DPGGRVSSPA
SSGVQAPHGG LPAAQSPCST LPGLCPGAGS FPS
//
