ID A0A2Y9ITT3_ENHLU Unreviewed; 634 AA.
AC A0A2Y9ITT3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Kelch-like protein 22 {ECO:0000256|ARBA:ARBA00019858};
GN Name=LOC111142736 {ECO:0000313|RefSeq:XP_022351734.1,
GN ECO:0000313|RefSeq:XP_022351735.1, ECO:0000313|RefSeq:XP_022351736.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022351736.1};
RN [1] {ECO:0000313|RefSeq:XP_022351734.1, ECO:0000313|RefSeq:XP_022351735.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022351734.1,
RC ECO:0000313|RefSeq:XP_022351735.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Cytoplasm,
CC cytosol {ECO:0000256|ARBA:ARBA00004514}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_022351734.1; XM_022496026.1.
DR RefSeq; XP_022351735.1; XM_022496027.1.
DR RefSeq; XP_022351736.1; XM_022496028.1.
DR STRING; 391180.A0A2Y9ITT3; -.
DR KEGG; elk:111142736; -.
DR OrthoDB; 5472491at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:InterPro.
DR GO; GO:0006513; P:protein monoubiquitination; IEA:InterPro.
DR CDD; cd18461; BACK_KLHL22; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030575; KLHL22_BACK.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF5; KELCH-LIKE PROTEIN 22; 1.
DR PANTHER; PTHR45632; LD33804P; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 2.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF13964; Kelch_6; 1.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 50..117
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 634 AA; 71716 MW; 0F6A7CD904EEB371 CRC64;
MAEEQEFTQL CKLPVQPSHP HCVNNTYRSA QHSQALLRGL LALRDSGILF DVVLVVEGRH
IEAHRILLAA SCDYFRGMFA GGLKEMEQEE VLIHGVSYNA MCQILHFIYT SELELSLSNV
QETLVAACQL QIPEIIHFCC DFLMSWVDEE NILDVYRLAE LFDLSRLTEQ LDTYILKNFV
AFSRTDKYRQ LPLEKVYSLL SSNRLEVSCE TEVYEGALLY HYTLEQVQAD QISLHEPPKL
LETVRFPLME AEVLQRLHDK LDPSPLRDTV ASALMYHRNE SLQPSLQGPQ TELRSDFQCV
VGFGGIHSTP STVLSDQAKY LNPLLGEWKH FTASLAPRMS NQGIAVLNNF VYLIGGDNNV
QGFRAESRCW RYDPRHNRWF QIQSLQQEHA DLCVCVVGRY IYAVAGRDYH NDLSAVERYD
PATNSWAYVA PLKREVYAHA GATLEGKMYV TCGRRGDDYL KETHCYDPDS NTWHSLADGP
VRRAWHGMAT LLDKLYVIGG SNNDAGYRRD VHQVACYSCT SGQWSSVCPL PAGHGEPGIA
VLDTRIYVLG GRSHNRGSRM GYVHIYDLEK DCWEEGPQLD NSISGLAACV LTLPRSLLLE
PPRGTPDRSQ ADPDFASEVM SVSDWEEFDN SSED
//
