ID A0A2Y9IUT2_ENHLU Unreviewed; 676 AA.
AC A0A2Y9IUT2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Methyl-CpG-binding domain protein 1 isoform X4 {ECO:0000313|RefSeq:XP_022351129.1};
GN Name=LOC111142386 {ECO:0000313|RefSeq:XP_022351129.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022351129.1};
RN [1] {ECO:0000313|RefSeq:XP_022351129.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022351129.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_022351129.1; XM_022495421.1.
DR AlphaFoldDB; A0A2Y9IUT2; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01396; MeCP2_MBD; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR002857; Znf_CXXC.
DR PANTHER; PTHR12396; METHYL-CPG BINDING PROTEIN, MBD; 1.
DR PANTHER; PTHR12396:SF59; METHYL-CPG-BINDING DOMAIN PROTEIN 1; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF02008; zf-CXXC; 3.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS51058; ZF_CXXC; 3.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00509}.
FT DOMAIN 1..69
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 169..216
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT DOMAIN 217..263
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT DOMAIN 308..356
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT REGION 75..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..98
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..302
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..535
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 74334 MW; D26729D7499A7E7E CRC64;
MAEDWLECPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
LFDFKQGILC YPAPKPQSLP VPSRKRKKPS RPAKTRKRQV GPQKGEVRKE APGDETKADA
DTAPASLPAP GCCENCGISF SGDGTRRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
ACRVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTREDCGRC
RVCLRPPRPG LRRQWRCVQR RCLRGKRSRR RGGCDSKMAA RRRPPRTQPL PPVPPSQPPA
SPELQPYTNR RQNRKCGACA ACLRRMDCGR CDFCCDKPKF GGSNQKRQKC RWRQCLQFAM
KRLLPSVWAG SEDGAGPPPP YSRRKRPGST RRPRLGQILK TLTTPTVRSG RAQTPMKQET
GSGFVLPPPG TDLVFLREGA SSPVQVPGPA TASTEALLQE AQCPGLSWVV ALPQVKQEKV
DAQEDWTPGT AILTSPVLLS GCPSKAVDAG LPPVKQEPLD PEEDKEEESK DDSASDLAPE
EEAGGAGTPV ITEIFSLGGT RLRDTAVWLP RGRERGRWRH GEGRGEDCAD SAPRLREEVG
STGVYGHHGD GTDFGPSHLP LTLLGAPWQP DLCTAEAGPA GLRRWDTAGD AAPHRKCTAS
DLASYRGRLR APLPKW
//