ID   A0A2Y9IUU8_ENHLU        Unreviewed;       306 AA.
AC   A0A2Y9IUU8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Palmitoyl-protein thioesterase 1 {ECO:0000256|ARBA:ARBA00014212};
DE            EC=3.1.2.22 {ECO:0000256|ARBA:ARBA00012423};
DE   AltName: Full=Palmitoyl-protein hydrolase 1 {ECO:0000256|ARBA:ARBA00031934};
GN   Name=LOC111143013 {ECO:0000313|RefSeq:XP_022352126.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022352126.1};
RN   [1] {ECO:0000313|RefSeq:XP_022352126.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022352126.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) +
CC         hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233,
CC         Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:74151; EC=3.1.2.22;
CC         Evidence={ECO:0000256|ARBA:ARBA00000072};
CC   -!- SIMILARITY: Belongs to the palmitoyl-protein thioesterase family.
CC       {ECO:0000256|ARBA:ARBA00010758}.
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DR   RefSeq; XP_022352126.1; XM_022496418.1.
DR   AlphaFoldDB; A0A2Y9IUU8; -.
DR   STRING; 391180.A0A2Y9IUU8; -.
DR   GlyCosmos; A0A2Y9IUU8; 3 sites, No reported glycans.
DR   KEGG; elk:111143013; -.
DR   OrthoDB; 760135at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002472; Palm_thioest.
DR   PANTHER; PTHR11247:SF8; PALMITOYL-PROTEIN THIOESTERASE 1; 1.
DR   PANTHER; PTHR11247; PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1; 1.
DR   Pfam; PF02089; Palm_thioest; 1.
DR   PRINTS; PR00414; PPTHIESTRASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..306
FT                   /note="Palmitoyl-protein thioesterase 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016078137"
SQ   SEQUENCE   306 AA;  34126 MW;  26E532AB04F5CD45 CRC64;
     MASPSCLWFL AVALLPGSCA ARALGHLDPA APLPLVIWHG MGDSCCNPLS MGAIKKMVEK
     KIPGIYVLSL EIGKTLMEDV ENSFFLNVNS QVTTVCEILA KDPKLQQGYN AMGFSQGGQF
     LRAVAQRCPS PPMINLISIG GQHQGVYGLP RCPGESSHIC DLIRKTLNAG AYNKAIQERL
     VQAEYWHDPV KEDMYRNHSI FLADINQERG VNESYKKNLM ALKKFVMVKF LNDSIVDPVD
     SEWFGFYRSG QAKETIPLQE TSLYTQDRLG LKEMDNAGQL VFLAVEGDHL QLSQEWFYAH
     IIPFLE
//