ID A0A2Y9IV47_ENHLU Unreviewed; 506 AA.
AC A0A2Y9IV47;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Nuclear factor erythroid 2-related factor 2 isoform X3 {ECO:0000313|RefSeq:XP_022351229.1};
GN Name=LOC111142427 {ECO:0000313|RefSeq:XP_022351229.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022351229.1};
RN [1] {ECO:0000313|RefSeq:XP_022351229.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022351229.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the bZIP family. CNC subfamily.
CC {ECO:0000256|ARBA:ARBA00008157}.
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DR RefSeq; XP_022351229.1; XM_022495521.1.
DR AlphaFoldDB; A0A2Y9IV47; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14720; bZIP_NFE2-like; 1.
DR Gene3D; 1.10.880.10; Transcription factor, Skn-1-like, DNA-binding domain; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR047167; NFE2-like.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR PANTHER; PTHR24411; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR; 1.
DR PANTHER; PTHR24411:SF3; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2; 1.
DR Pfam; PF03131; bZIP_Maf; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; A DNA-binding domain in eukaryotic transcription factors; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 398..461
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 233..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 416..443
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 233..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 506 AA; 56169 MW; 81762CFFB39C541E CRC64;
MKKQVADIPK PDALYFDDCM QLLAETFPFV DDNEVSSAAF QSLVPDIPSQ METPVFVAPN
QAQSSQTLLV QSVIADLDNM QQDIEQVWEE LLSIPELQCL NIQNDKLVET NTVPSPETKM
TEIDNSYHFY SSVPSLEKEV GNCSPHFLNA FEDSFSSILS TEDSSQLTVS SLNSDATINT
DFGDEFYSAF IAEPSSSNSV PSSATLSQSL SELFNGPIDV SDLSLCKAFN QNQPESTEFN
DSDSGISLNT SPGMASPEHS VESSVYGDTP LGFSDSEMEE IDSAPGSVKQ NGPKTQPVQS
AGDTAEPLSP SPGHSAPARD TQGENTPKKE LPVSPGHRKT PFTKDKHSSR LEAHLTRDEL
RAKALHIPFP VEKIINLPVD DFNEMMSKEQ FNEAQLALIR DIRRRGKNKV AAQNCRKRKL
ENIVELEQDL DHLKDEKEKL LKEKGENDKS LHLLKKQLST LYLEVFSMLR DEDGKPYSPS
EYSLQQTRDG NVFLVPKSKK PDMKKN
//
