ID A0A2Y9IXJ9_ENHLU Unreviewed; 2343 AA.
AC A0A2Y9IXJ9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Stabilin-2 isoform X3 {ECO:0000313|RefSeq:XP_022350675.1};
GN Name=LOC111142039 {ECO:0000313|RefSeq:XP_022350675.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022350675.1};
RN [1] {ECO:0000313|RefSeq:XP_022350675.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022350675.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022350675.1; XM_022494967.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.30.180.10; FAS1 domain; 6.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR036378; FAS1_dom_sf.
DR InterPro; IPR000782; FAS1_domain.
DR InterPro; IPR000538; Link_dom.
DR PANTHER; PTHR24038; STABILIN; 1.
DR PANTHER; PTHR24038:SF0; STABILIN-2; 1.
DR Pfam; PF12947; EGF_3; 11.
DR Pfam; PF02469; Fasciclin; 6.
DR Pfam; PF00193; Xlink; 1.
DR SMART; SM00181; EGF; 22.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00554; FAS1; 6.
DR SMART; SM00445; LINK; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF82153; FAS1 domain; 6.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 11.
DR PROSITE; PS50026; EGF_3; 18.
DR PROSITE; PS50213; FAS1; 6.
DR PROSITE; PS01241; LINK_1; 1.
DR PROSITE; PS50963; LINK_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..2343
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015987127"
FT DOMAIN 107..147
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 155..192
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 194..235
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 236..275
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 321..361
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 370..504
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 514..651
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 735..775
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 825..865
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 866..908
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 909..951
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 993..1126
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1136..1264
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1345..1383
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1390..1427
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1431..1469
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1470..1511
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1512..1553
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1554..1593
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1595..1723
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1739..1880
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1957..1997
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2004..2041
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2122..2164
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2197..2290
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DISULFID 137..146
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 163..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 182..191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 765..774
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1373..1382
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1398..1415
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1417..1426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1435..1445
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1987..1996
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2031..2040
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2219..2288
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 2243..2264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
SQ SEQUENCE 2343 AA; 254465 MW; 61B1707A3613D0AA CRC64;
MLQNLVLFLL GLVVHNSCSP PETTDQAKRC DKKSMLTIRT ECQSCSLNLG VQCPDGYTKV
TNGSVGVRDC RYIFEIRKYS LSLPGCRHIC RKEYVQPQCC PGHWGPDCME CPGGASSPCS
GRGICAEGME GNGTCSCQDG FGGTACKTCA EDNLFGPSCS AVCSCVHGVC NSGIDGDGSC
ECYSAYTGPN CDKPIPECAA LLCPENSRCS PSSQDETKLE CKCLPNYRGD GHYCEPINPC
LQAICHPHAH CTYLGPNRHS CTCQEGYHGD GQVCLPVDPC QTHYGNCPTE STVCIYDGPG
QSHCECKEHY HNYVPGVGCS IINVCESNNP CHKNANCTTI APGQPKCTCQ KGYVGDGSTC
YGNIMERLRE LNTEPRGKWQ GKLTSFISLL DKAYAWPLSK LGPFTVLLPT DKGLKGFNIK
ELLMDKEAAQ YFVKLHIIAG QMNTQRMNNT NTFYTLTGKS GEIFNGDNDN QLKLKLYGGK
NNVKIIQGDI VASNGLLHIL DRAMDKMAPT FESNTEQTIM TMLQPRYSKF RSLLEETNVG
HALDEDGTGG PYTIFVPSNE ALNNMKDGTL DYLLSPEGSR KLLELVRYHI VPFTQLEVAT
LIVTPHIRTL ANQIIQFNTT SNGQILANDV AIEETEVIAK NGRIYTLTGV LIPPSIMPIL
PHRCDESKRE MKLGTCVSCS LVYWSKCPAN SEPTTLFTHR CVYTGRVRSL KSGCARYCNA
TVQIPKCCKG FYGPDCNQCP GGFSNPCSGN GQCVDGLNGN GTCVCQDGFQ GSQCQFCSDP
NKYGPRCDKK CLCISGTCNN RIDSDGACLD GTCREGSAGR FCHKQTSTCG PYMQFCHIHA
TCEYSNGTAS CVCKPGYKGD GRLCSEMDPC AEITRGGCSQ NAECVRTGMG THTCVCQQGW
TGDGRDCSEI NHCLLPGAGG CHANATCLYV GPGQNECECK QGFRGDGIDC EAVTSCWEQT
GKCHPLATCQ LTPSGLWSCV CQEGYEGDGL LCYGNAAVEL SFLSAAAIFN QWINNASLQP
MLSAASNLTV LVPSQQAIED MDQDEKTFWL SKSNIPVLIK YHMLLGTYRV ADLQALSSSD
MLATSLPGNF LHLAKADETV TIEGASVIDG DNAATNGVIH IINKVLVPQR SLTVSLPNLL
TRLDQMPNYS IFRGYIIQYN LASVIEAASA YTVFAPNNDA IENYIREKKV TTLEEDVIRY
HVILEEKLLK NDLHQGMHRE TMMGFSYLLG FFLHDDQLYV NEAPINYTNA ATDKGVIHGL
GKVLEIQKNR CDNNDTTIVR GKCGKCLQQP VCPFGTKQLG EEMRRCIYTI YFMGKRSLFI
GCQAKCVKTI ITRECCAGFF GPQCQPCPGR AENVCFGNGI CLDGVNGTGV CECGDGFSGT
ACETCVEGKY GPHCDQGCSC VHGRCNQGPS GDGSCECDVG WRGVSCDTEI TKDDCNGICH
TSANCLLNPD GTASCKCTAG FQGNGTVCTA INACETSNGG CSTKADCRRT TPGSRQCVCR
AGYTGDGIVC LEINPCLENN GGCHKNAECT QTGPNQAVCN CLPKYTGDGK VCTLINTCLT
KNGGCSEFAI CNHTGLEERT CTCKPNYIGD GFTCRGNIYQ ELPRNPKTSQ YFFQLLEHSV
RDLSGPGPFT VFAPLSAAFD EEPQIKDWDK QGFMPQVLRY HVIACHQLLL ENLKLIPNAT
SLQGESIVIS VSEDTVYINN KAKIISSDII NTNGIIHIID KLLSPQNLLF TPKDASGRIV
QNLTTVATNH GYTKFSNLLQ DVGLLGVITD PIHTPVTLFW PSDRALQALP PEQQDFLFNQ
DNKDKLKEYL KFHVIRDSKI LAVDLPRATA WKTLQGSELG VTCGAGSDIG ELFLNDQTCR
IVQRELLFDL GVAYGIDCLL IDPTLGGRCD TFATYNFSGD CWSCANTPSC PRWSKPKGVK
QKCRYNMSFK GYLEGCREQC TMVIRLPRCC KGYFGRDCQA CPGGADAPCS NRGVCLDQYS
GIGECRCNTG FNGTACELCL PGRFGPDCQP CGCSAHGQCD DGPTGSGQCF CETGWTGHFC
DIQTALPPVC TPSCSAHATC KENNTCECNL NYEGDGITCT VVDFCKQNNG GCAKVARCSQ
KGTKVSCSCL KGYKGDGRSC TEIDPCADGL NGGCHEHATC KMTGPGKHKC ECKSHYVGDG
TDCEPEQLPI DRCLQDNGQC HADADCADLH FQDTTVGVFH LRSPLGQYKL TFDKAKEACA
NEAASMATYN QLSYAQKAKY HLCSAGWLES GRVAYPTAYA SQNCGSGVVG IIDYGQRNNK
SEMWDVFCYR MKDVNCTCKA GYVGDGFSCS GNLLQVLMSF PSLTNFLTLY FRPQDSLRKE
KCS
//
