ID   A0A2Y9IY38_ENHLU        Unreviewed;       680 AA.
AC   A0A2Y9IY38;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Forkhead box protein P1 isoform X1 {ECO:0000313|RefSeq:XP_022353286.1};
GN   Name=LOC111143744 {ECO:0000313|RefSeq:XP_022353286.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022353286.1};
RN   [1] {ECO:0000313|RefSeq:XP_022353286.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022353286.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   RefSeq; XP_022353286.1; XM_022497578.1.
DR   AlphaFoldDB; A0A2Y9IY38; -.
DR   KEGG; elk:111143744; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd20065; FH_FOXP2; 1.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR047412; FH_FOXP1_P2.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR032354; FOXP-CC.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR   PANTHER; PTHR45796:SF3; FORKHEAD BOX PROTEIN P1; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF16159; FOXP-CC; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          467..540
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        467..540
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          271..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          614..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..288
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        392..407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..628
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   680 AA;  76391 MW;  3DE5360653CD4854 CRC64;
     MFQCVFSSSV LQPHSTSCLF KHLFYHSATP ASQKQPEPIY SKKTEIQRQT VRAHSVKLFI
     FSALQVARQL LLQQQQQQQV SGLKSPKRND KQPALQVPVS VAMMTPQVIT PQQMQQILQQ
     QVLSPQQLQV LLQQQQALML QQQQLQEFYK KQQEQLQLQL LQQQHAGKQP KEQQQVATQQ
     LAFQQQLLQM QQLQQQHLLS LQRQGLLTIQ PGQPALPLQP LAQGMIPTEL QQLWKEVTSA
     HSAEESTGSN HSSLDLTTTC VSSSAPSKTS LIMNPHASTN GQLSVHTPKR ESLSHEEHPH
     SHPLYGHGVC KWPGCEAVCE DFQSFLKHLN SEHALDDRST AQCRVQMQVV QQLELQLAKD
     KERLQAMMTH LHVKSTEPKA APQPLNLVSS VTLSKSASEA SPQSLPHTPT TPTAPITPVT
     QGPSVITTTS MHTVGPIRRR YSDKYNVPIS SADIAQNQEF YKNAEVRPPF TYASLIRQAI
     LESPEKQLTL NEIYNWFTRM FAYFRRNAAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE
     VEFQKRRPQK ISGNPSLIKN MQTSHAYCTP LNAALQQASM AENSIPLYTT ASMGNPTLGN
     LASAIREELN GAMEHTNSNE SDSSPGRSPL QAVHPVHVKE EPLDPEEAEG PLSLVTTANH
     SPDFDHDRDY EDEPVNEDME
//