ID   A0A2Y9J0D2_ENHLU        Unreviewed;      1236 AA.
AC   A0A2Y9J0D2;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Cullin-associated NEDD8-dissociated protein 2 isoform X2 {ECO:0000313|RefSeq:XP_022354021.1};
GN   Name=LOC111144149 {ECO:0000313|RefSeq:XP_022354021.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022354021.1};
RN   [1] {ECO:0000313|RefSeq:XP_022354021.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022354021.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CAND family.
CC       {ECO:0000256|ARBA:ARBA00007657}.
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DR   RefSeq; XP_022354021.1; XM_022498313.1.
DR   AlphaFoldDB; A0A2Y9J0D2; -.
DR   STRING; 391180.A0A2Y9J0D2; -.
DR   OrthoDB; 68829at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0010265; P:SCF complex assembly; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039852; CAND1/CAND2.
DR   InterPro; IPR013932; TATA-bd_TIP120.
DR   PANTHER; PTHR12696:SF2; CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 2; 1.
DR   PANTHER; PTHR12696; TIP120; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF08623; TIP120; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1045..1207
FT                   /note="TATA-binding protein interacting (TIP20)"
FT                   /evidence="ECO:0000259|Pfam:PF08623"
FT   REGION          315..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        317..344
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1236 AA;  134686 MW;  32736A539B2721D6 CRC64;
     MSTAAFHISS LLEKMTSSDK DFRFMATSDL MSELQKDSIQ LDEDSERKVV KMLLKLLEDK
     NGEVQNLAVK CLGPLVGKVK EYQVETIVDA LCTNMRSDKE QLRDIAGIGL KTVLSELPPA
     ATGSGLAANV CRKITGQLTS AIAQQEDVAV QLEALDILSD MLSRLGAPLG AFHASLLHCL
     LPQLNSPRLA VRKRAVGALG HLAAACSTDL FVELADHLLD RLPGPRAPAS PAAIRTLIQC
     LGSVGRQAGH RLGAHLDRLV PLVEEFCNVD DDELRESCLQ ALEAFLRKCP KEMGPHVPNV
     TSLCLQYMKH DPNYNYDSDG DEEEMETEDN EFSEQGSEDE YSDDDDMSWK VRRAAAKCMA
     ALIGSRPDLL PDFHSTLAPA LIHRFKEREE NVKADVFGAY IVLLRQTRPP KGWLGSMEEP
     TQTGISLHAL HGQVPLVIKA LQRQLKDRSV RARQGCFNLL TELAGVLPGS LAEHMPVLVA
     GIVFSLADRS SSSTIRMDAL AFLQGLLGTE PAEAFHSHLP TLLPPVMACV ADPFYKIAAE
     ALLVLQELVR ALWPLDRPRT LDPEPYVGEM SAATLARLRA TDLDQEVKER AISCMGHLVA
     HLGDQLGDDL QPSLLLLLDR LRNEITRLPA VKALTLVAVS PLRLDLQPIV AEALPILASF
     LRKNQRALQL ATLAALDSLA QTQGHSLPPS AVQAVLAELP ALVNESDMHV AQLAVDFLAT
     MTQAQPASLA KVSGPVLLEL LRLLRSPLLP ASVLAAAEGF LQALVGTRPP CMDYKELIRM
     LTAPVYDQAA EGGPGLHKQV FHSLARCVAA LAAACPQEAA GTANRLVCDA RSPNSSTGVK
     VLAFLSLAEV GQVAGPGPQR ELKAVLLEAL GSPSEDVRAA ASYALGRVGA GNLPDFLPFL
     LGQIEAEPRR QYLLLHALRE ALGAAQPDSL KPYAEDIWAL LFQRCEGAEE GTRGVVAECI
     SKLVLANPPF LLPRFQKQLA AGRPHTRSTV ITAVKFLISD QPHPIDPLLK SLIGEFMESL
     QDPDLNVRRA TLAFFNSAVH NKPSLVRDLL DDILPLLYQE TKIRRDLIRE VEMGPFKHTV
     DDGLDVRKAA FECMYSLLES CLGRLDICEF LNHVEDGLKD HYDIRMLTFI MLARLATLCP
     APVLQRVDRL IEPLRATCTA KVKAGSVKQE FEKQDELKRS AMRAVAALLT IPEVGKSPIM
     ADFSSQIRSN PELAALFESI QKDSASAPNT DSMELS
//