ID A0A2Y9J0F1_ENHLU Unreviewed; 855 AA.
AC A0A2Y9J0F1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=DNA repair protein complementing XP-C cells isoform X3 {ECO:0000313|RefSeq:XP_022354041.1};
GN Name=LOC111144158 {ECO:0000313|RefSeq:XP_022354041.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022354041.1};
RN [1] {ECO:0000313|RefSeq:XP_022354041.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022354041.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR RefSeq; XP_022354041.1; XM_022498333.1.
DR AlphaFoldDB; A0A2Y9J0F1; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR018026; DNA_repair_Rad4-like.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR NCBIfam; TIGR00605; rad4; 1.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 546..598
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 600..660
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 667..741
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 95689 MW; 6B07AB0200F92526 CRC64;
MVRKRAAGRE PQGREPCGRK AKGESMAGRE KKEADVLEDE KPLKTSLLSK VSQGKRKRGC
SDPGGPAHGP AKKKVAKVTV KSENPTVVKD EALSDGEEFR DFTKGSKKAQ PPRREAAVDK
GSCEGDNEEE SEDDWEEVEE LGEPVPGDMG EKTAFFESVL PVEPVEIEIE TPQQAKARER
SERIKVEFET YLRRMMKRFS KEVHEDTHKV HLLCLLANGF YRSNICSQPD LLAISLSIIP
ARFTRVPPQD VDACYLSNLV KWFVGTFTVN ADLSTNERDD LQTTLERRFA IYSARDDEEL
VHIFLLILRA LQLSTRLVLS LQPIPLKLPP AKGKKAPKAT SAEGAGGSLE TCSPVLESQT
KPKTSQGTRE EVTSSKGPGR PSAKGKRSKA ATVRKKQRGP SSREEEHKAG GQQEDTQRCR
HGRERQVASR VSYKEESGSD KGSSGSDFEL SSGEAHHSSD EDSEPGLPRQ RSKAGSRSDS
RTQRRRHPKH PGFPAASTSS SSSKSKRGKK ISSDGEGAER GKAAGVDQWL EVFCEQEEKW
FQAKHLGQPL PTVIGTYKNH PLYALKRHLL KYEAIYPETA AILGYCRGEA VYSRDCVHTL
HSRDTWLKQA RVVRLGEVPY KMVKGYSNRA RKARLAEPQL QDHNDLGLFG EWQTEEYQPP
VAVDGKVPRN EFGNVYLFLP SMMPIGCVQL NLPNLHRVAR KLDIDCVQAI TGFDFHKGYS
HPITDGYIVC EEYKDVLLAA WEKEQALIEK REKEKREKRA LGNWKLLVRG LLIRERLKLR
YGDKREERAL QGPAGGGLSS DEEEGTSSQA EASRILAASW PQNREAEEEQ KPKCPKKTKR
EKAASASHLF PFERL
//