ID A0A2Y9J1I7_ENHLU Unreviewed; 564 AA.
AC A0A2Y9J1I7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=PX domain-containing protein kinase-like protein isoform X6 {ECO:0000313|RefSeq:XP_022353544.1};
GN Name=LOC111143864 {ECO:0000313|RefSeq:XP_022353544.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022353544.1};
RN [1] {ECO:0000313|RefSeq:XP_022353544.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022353544.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022353544.1; XM_022497836.1.
DR AlphaFoldDB; A0A2Y9J1I7; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd22062; WH2_DdVASP-like; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR22999:SF40; PX DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN; 1.
DR PANTHER; PTHR22999; PX SERINE/THREONINE KINASE PXK; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|RefSeq:XP_022353544.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transferase {ECO:0000313|RefSeq:XP_022353544.1}.
FT DOMAIN 1..109
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 71..464
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 534..553
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 420..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..516
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 63235 MW; 81585EE9276B68B4 CRC64;
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTIVRRYS DFDLLNNSLQ IAGLSLPLPP
KKLIGNMDRE FIAERQKGLQ NYLNVITTNH ILSNCELVKK FLDPNNYSAN YTEIALQQVS
MFFRSEPKWE VVEPLKDIGW RIRKKYFLMK IKNQPKERLV LSWADLGPDK FLSDKDFQCL
IKLLPSCSHP YIYRVTFATA NESSALLIRM FNEKGTLKDL IYKAKPKDPF LKKYCNPKKI
QGLELQQIKT YGRQILEVLK FLHDKGFPYG HLHASNVMLD GDTCRLLDLE NSLLGLPSFY
RSYFSQFRKI NTLESMDVHC FGHLLYEMTY GRPPDSVPVD SFPPAPSMAV VAVLESTLSC
EACKNGMPAV SRLLQMPLFS DVLLTTSEKP QFKIPTKLKE ALRIAKECIE KRLIEEQKQI
HQHRRLTRAQ SHHGSEEERK KRKILARKKS KRSAIENSEE HSAKYSNSNN SGSGASSPLT
SPSSPTPPST AGMSALPPPP PPPPPPPPPP AAPLLPVSTE APTQLLPQAV NGVSRGALLS
SIQNFQKGTL RKAETCDHSA PKIG
//
