ID A0A2Y9J1V6_ENHLU Unreviewed; 835 AA.
AC A0A2Y9J1V6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Zinc finger protein 2 homolog isoform X2 {ECO:0000313|RefSeq:XP_022354827.1};
GN Name=LOC111144697 {ECO:0000313|RefSeq:XP_022354827.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022354827.1};
RN [1] {ECO:0000313|RefSeq:XP_022354827.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022354827.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR RefSeq; XP_022354827.1; XM_022499119.1.
DR AlphaFoldDB; A0A2Y9J1V6; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 18.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF132; ZINC FINGER PROTEIN 939; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 17.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 10.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 21..92
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 308..335
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 363..390
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 391..418
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 419..446
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 447..474
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 475..502
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 503..530
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 531..558
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 559..586
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 587..614
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 615..642
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 643..670
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 671..698
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 699..726
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 727..754
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 755..782
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 783..810
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 811..835
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 835 AA; 97613 MW; 05897DAFC0F9F114 CRC64;
MCHPNSDDFR LNRNVLFQGS LSFGDVTVDF SQEEWQHLDP AQRTLYRDVM LENYHNFVSV
GYPIKKPEVI FKLEEGKEPW ILEEEFLYQN YPDSRAYYVA ERIQKNQDKY LPHVLFNNKK
VTSKKVYALR KSSNKSTDFI PSRKIPCKHD LHGMNLKNIL VSIGSNRYFS RKKPHMLNVY
EQLLDIKQEK PHTQEGSHEN NQYEKALGHK NGIIQHVNTQ SSEKTLKYDG GKSLGKKTTI
IPHRQIDTGE KLCEYNGHGE TCEKSSLLKC YGVSFEMKQC KGNKIENNFS RMSHFTQVQK
KKRCEGLFKC SECGKTFNYK SNLTVHQKTH MGEKPHEFNS CGKTSHKSPL TDHQLAHIGE
KLYKYSECGK SFCKKSSLTQ HEETNIGRKP HECNDCGKTF CKKSAFTQHQ RIHTGEKHFQ
CNECSKTFHR QSDIKVHQRI HKGEKRFQCN ECGKTFHWQS DIKLHQRIHT GEKPFQCSKC
GKTFYRQADV NAHQRIHTGE KRFQCNECGK TFYWQSDVHA HQRTHTGEKP FRCNECGKSF
HRQSDVNVHQ RTHTGEKRFQ CKECGKTFYR QSDVNAHQRI HTGQKPFQCN ECGKTFYRQS
DVNVHQRTHT GEKRFRCNEC GKTFYRQSEV NVHQRTHTGE KPFQCNECGK TFYRQSDVNA
HQRIHTGEKP YKCNECGKSF YEKSSLTRHE RTHTGEKPYE CNECRRTFCQ KSALTQHQRT
HTGDRPFRCN VCGKTYCHLS AINVHQRTHT GEKPFQCHEC EKSFLTKSTL INHQRTHTGE
KPFECNECGK SFRHKSTLTT HLRIHSGEKP YKCCECGKTF GRKSALTNHQ GIHLG
//
