ID   A0A2Y9J1Z0_ENHLU        Unreviewed;       688 AA.
AC   A0A2Y9J1Z0;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Alpha-actinin-2 isoform X4 {ECO:0000313|RefSeq:XP_022354862.1};
GN   Name=LOC111144713 {ECO:0000313|RefSeq:XP_022354862.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022354862.1};
RN   [1] {ECO:0000313|RefSeq:XP_022354862.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022354862.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022354862.1; XM_022499154.1.
DR   AlphaFoldDB; A0A2Y9J1Z0; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.20.58.60; -; 4.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF429; ALPHA-ACTININ-2; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   Pfam; PF00435; Spectrin; 4.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM01184; efhand_Ca_insen; 1.
DR   SMART; SM00150; SPEC; 3.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 4.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          547..582
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          583..618
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   COILED          66..93
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          231..265
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          465..499
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   688 AA;  79973 MW;  2134B307CC3BE66E CRC64;
     MTYVSCYYHA FAGAQKVRTN LKASLALWKD PPPRSILCMR VPVHRAVLFT YCVLQAETAA
     NRICKVLAVN QENERLMEEY ERLASELLEW IRRTIPWLEN RTPEKTMQAM QKKLEDFRDY
     RRKHKPPKVQ EKCQLEINFN TLQTKLRISN RPAFMPSEGK MVSDIAGAWQ RLEQAEKGYE
     EWLLNEIRRL ERVEHLAEKF RQKASTHETW AYGKEQILLQ KDYESASLTE VRALLRKHEA
     FESDLAAHQD RVEQIAAIAQ ELNELDYHDA VNVNDRCQKI CDQWDRLGTL TQKRREALER
     TEKLLETIDQ LHLEFAKRAA PFNNWMEGAM EDLQDMFIVH SIEEIQSLIT AHEQFKATLP
     EADGERQSIM AIQNEVEKVI QSYNIRISSS NPYSTVTMDE LRAKWDKVKQ LVPIRDQSLQ
     EELARQHANE RLRRQFAAQA NAIGPWIQNK MEEIARSSIQ ITGALEDQMN QLKQYEHNII
     NYKNNIDKLE GDHQLIQEAL VFDNKHTNYT MEHIRVGWEV LLTTIARTIN EVETQILTRD
     AKGITQEQMN EFRASFNHFD RRKNGLMDHE DFRACLISMG YDLGEAEFAR IMTLVDPNGQ
     GTVTFQSFID FMTRETADTD TAEQVIASFR ILASDKPYIL AEELRRELPP DQAQYCIKRM
     PAYSGPGSVP GALDYTAFSS ALYGESDL
//