ID A0A2Y9J3A6_ENHLU Unreviewed; 598 AA.
AC A0A2Y9J3A6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Methyl-CpG-binding domain protein 4 isoform X1 {ECO:0000313|RefSeq:XP_022354203.1};
DE SubName: Full=Methyl-CpG-binding domain protein 4 isoform X2 {ECO:0000313|RefSeq:XP_022354204.1};
GN Name=LOC111144268 {ECO:0000313|RefSeq:XP_022354203.1,
GN ECO:0000313|RefSeq:XP_022354204.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022354204.1};
RN [1] {ECO:0000313|RefSeq:XP_022354203.1, ECO:0000313|RefSeq:XP_022354204.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022354203.1,
RC ECO:0000313|RefSeq:XP_022354204.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022354203.1; XM_022498495.1.
DR RefSeq; XP_022354204.1; XM_022498496.1.
DR STRING; 391180.A0A2Y9J3A6; -.
DR KEGG; elk:111144268; -.
DR OrthoDB; 1451962at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008263; F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd01396; MeCP2_MBD; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR011257; DNA_glycosylase.
DR InterPro; IPR017352; MBD4.
DR InterPro; IPR045138; MeCP2/MBD4.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR PANTHER; PTHR15074:SF7; METHYL-CPG-BINDING DOMAIN PROTEIN 4; 1.
DR PANTHER; PTHR15074; METHYL-CPG-BINDING PROTEIN; 1.
DR Pfam; PF01429; MBD; 1.
DR PIRSF; PIRSF038005; Methyl_CpG_bd_MBD4; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF48150; DNA-glycosylase; 1.
DR PROSITE; PS50982; MBD; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 71..143
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 67933 MW; 438770EBF97C9049 CRC64;
MESPSLGDCG AAPSVTSSER SAADRHCDLR QEDGALGLES MGENEKQVMI KNSSECNPLL
QESIASAQTS DTTMTECHKS VPCGWERVVK QRLSGKTAGR YDIYFISPQG LKFRSKSSLV
KYLHKNEETS LTPEDFDFTV LSKKGIKSGY KNCNIAPLTS QMQSESNSSN WNLRTRSWWK
KDVFPLPSSC LELPSSKGLS NFKDKGVNDV DSRKVRKSKE KVPILKGIQI KRTKTRCQKG
LPDSAQSNKK RKSEYKKADD ESESVVQESQ LDKTLSIAGA GTSNKTLSAT SEEKKLVKEQ
SLSLVSNFCS EQITSGIINK LCSTEEAEHS KKCEETFLES EEIKSKVQVG ERKEHLHTDI
LKCGSEMDNN CSQTEKDSVE MCQEDTILRT QIEKRKTSLY FSSKYNREAL SPPRRKAFKK
WTPPRSPFNL VQETLFHDPW KLLIATIFLN RTSGKMAIPV LWEFLEKYPS AEVARTADWR
DVSELLKPLG LYDLRAKTII KFSDEYLTKQ WRYPIELHGI GKYGNDSYRI FCVNEWKQVR
PTPSRNMSST FCLWGKISPS LEPKLFLGHM CYHSHNQFCS RLEGQVVAWG YRQQGEDP
//
