ID   A0A2Y9J3H4_ENHLU        Unreviewed;       555 AA.
AC   A0A2Y9J3H4;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Vacuolar fusion protein MON1 homolog {ECO:0000256|RuleBase:RU367048};
GN   Name=LOC111144318 {ECO:0000313|RefSeq:XP_022354269.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022354269.1};
RN   [1] {ECO:0000313|RefSeq:XP_022354269.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022354269.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Plays an important role in membrane trafficking through the
CC       secretory apparatus. {ECO:0000256|RuleBase:RU367048}.
CC   -!- SIMILARITY: Belongs to the MON1/SAND family.
CC       {ECO:0000256|ARBA:ARBA00008968, ECO:0000256|RuleBase:RU367048}.
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DR   RefSeq; XP_022354269.1; XM_022498561.1.
DR   AlphaFoldDB; A0A2Y9J3H4; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0006623; P:protein targeting to vacuole; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR004353; Mon1.
DR   PANTHER; PTHR13027; SAND PROTEIN-RELATED; 1.
DR   PANTHER; PTHR13027:SF14; VACUOLAR FUSION PROTEIN MON1 HOMOLOG A; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
DR   PRINTS; PR01546; YEAST73DUF.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          156..278
FT                   /note="FUZ/MON1/HPS1 first Longin"
FT                   /evidence="ECO:0000259|Pfam:PF19036"
FT   DOMAIN          317..414
FT                   /note="FUZ/MON1/HPS1 second Longin"
FT                   /evidence="ECO:0000259|Pfam:PF19037"
FT   DOMAIN          444..544
FT                   /note="FUZ/MON1/HPS1 third Longin"
FT                   /evidence="ECO:0000259|Pfam:PF19038"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   555 AA;  61677 MW;  FF6FB6E0DE35C8F6 CRC64;
     MAADMQRKRS SGCPDGTLAP SDGQNMERAE SPTPGLAQGM EPGAGQEGAM FVHARSYEDL
     TESEDGAASG DSPKEGAGGP PPLPADMRQI SQDFSELSTQ LTGVARDLQE EMLPGSSEDW
     PESSGAVGRP APEPLREGAG EGDEEEAAEA WRLHQKHVFV LSEAGKPVYS RYGSEEALSS
     TMGVMVALVS FLEADKNAIR SIHADGYKVV FVRRSPLVLV AVARTRQSAQ ELAQELLYIY
     YQILSLLTGA QLSHIFQQKQ NYDLRRLLSG SERITDNLLQ LMARDPSFLM GAARCLPLAA
     AVRDAVSVSL QQARARSLVF SILLARNQLV ALVRRKDQFL HPIDLHLLFN LISSSSSFRE
     GEAWTPVCLP KFNAAGFFHA HISYLEPDTD LCLLLVSTDR EDFFAVSDCR RRFQERLRKR
     GAHLALREAL RTPYYSVAQV GIPDLRHFLY KSKSSGLFTS PEIEAPYTSE EEQERLLGLY
     QYLHSRAHNA SRPLKTIYYT GPNENLLAWV TGAFELYMCY SPLGTKASAV SAIHKLMRWI
     RKEEDRLFIL TPLTY
//