ID A0A2Y9J3R9_ENHLU Unreviewed; 553 AA.
AC A0A2Y9J3R9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Mucolipin-3 isoform X1 {ECO:0000313|RefSeq:XP_022352710.1};
GN Name=LOC111143331 {ECO:0000313|RefSeq:XP_022352710.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022352710.1};
RN [1] {ECO:0000313|RefSeq:XP_022352710.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022352710.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022352710.1; XM_022497002.1.
DR AlphaFoldDB; A0A2Y9J3R9; -.
DR STRING; 391180.A0A2Y9J3R9; -.
DR KEGG; elk:111143331; -.
DR OrthoDB; 2877219at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR CDD; cd21072; ELD_TRPML3; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR047317; MCOLN3_ELD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF5; MUCOLIPIN-3; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..270
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 371..508
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 553 AA; 64243 MW; C7514888023FCE62 CRC64;
MASPVVVISS CSSHEEENRG TFNQHTSLSE ELLLEDQMRR KLKFFFMNPC EKFWARGRKP
WKLAIQILKI AVVTIQLVFF GLSNQMVVAF KEENTIAFKH LFLKGYMDRM DDTYAVYTQS
DVYHQIIFAV NQYLQLRNTS VGNHAYEKKG MEQSAMAICQ RFYRQGNICP GNDTFDIDPE
IETECFFVEP DEPFHIGALE ENKLNLTLDF HRLLTVELQF KLKAINLQTI RHHELPDCYD
FSLTITFDNK AHSGRIKISL DNDISIRECK DWHVSGSIQK NTHYMMIFDA LVILTCLASL
ILCLRSVIRG LQLQQEFVNF FLLHYKKEVS VSDRMEFVSG WYIMIIISDI LTIIGSILKM
EIQAKSLTSY DVCSILLGTS TMLVWLGVIR YLGFFQKYNL LILTLQAALP NVIRFCCCAA
MIYLGYCFCG WIVLGPYHDK FRSLNMVSEC LFSLINGDDM FATFAKMQQK SYLVWLFSRT
YLYSFISLFI YMILSLFIAL ITDTYETIKH YQQDGFPETE LRTFISECKD LPNSGKYRLE
DDTPVSIFCC CKK
//
