ID   A0A2Y9J436_ENHLU        Unreviewed;       876 AA.
AC   A0A2Y9J436;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=Pre-mRNA-splicing factor CWC22 homolog {ECO:0000256|ARBA:ARBA00040488};
DE   AltName: Full=Nucampholin homolog {ECO:0000256|ARBA:ARBA00042174};
GN   Name=LOC111145224 {ECO:0000313|RefSeq:XP_022355713.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022355713.1};
RN   [1] {ECO:0000313|RefSeq:XP_022355713.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022355713.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC   -!- SIMILARITY: Belongs to the CWC22 family.
CC       {ECO:0000256|ARBA:ARBA00006856}.
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DR   RefSeq; XP_022355713.1; XM_022500005.1.
DR   AlphaFoldDB; A0A2Y9J436; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   Gene3D; 1.25.40.180; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   PANTHER; PTHR18034; CELL CYCLE CONTROL PROTEIN CWF22-RELATED; 1.
DR   PANTHER; PTHR18034:SF3; PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG; 1.
DR   Pfam; PF02847; MA3; 1.
DR   SMART; SM00544; MA3; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS51366; MI; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          421..537
FT                   /note="MI"
FT                   /evidence="ECO:0000259|PROSITE:PS51366"
FT   REGION          1..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          621..876
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..404
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        629..679
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..749
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        766..819
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        827..876
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   876 AA;  101634 MW;  014B7B59774CB762 CRC64;
     MTEGKIIIPI REPLLQKTDY EHSRRGRSYD SSMESRSRDR EKRRERERDM DRKRSWKSPT
     PGRRSPEPSV TQSSSAQDEP TAKKKKDELD PLLTRTGGAY IPPAKLRMMQ EQITDKNSLA
     YQRMSWEALK KSINGLINKV NISNIGIIIQ ELLQENIVRG RGLLSRSVLQ AQSASPIFTH
     VYAALVAIIN SKFPQIGELI LKRLILNFRK GYRRNDKQLC LTASKFVAHL INQNVAHEVL
     CLEMLTLLLE RPTDDSVEVA IGFLKECGLK LTQVSPRGIN AIFERLRNIL HESEIDKRVQ
     YMIEVMFAVR KDGFKDHPVI LEGLDLVEED DQFTHMLPLE DDYNPEDVLN VFKMDPNFME
     NEEKYKAIKK EILDEGDSDS NTDQDAGSSE EEEEEEDEEG EEDEEGQKVT IHDKTEINLV
     SFRRTIYLAI QSSLDFEECA HKLLKMEFPE SQTKELCNMI LDCCAQQRTY EKFFGLLAGR
     FCMLKKEYME SFESIFKEQY DTIHRLETNK LRNVAKMFAH LLYTDSLPWS VLECIKLSEE
     TTTSSSRIFV KIFFQELCEY MGLPKLNARL KDETLQPFFE GLLPRDNPRN TRFAINFFTS
     IGLGGLTDEL REHLKNTPKV IVAQKPDVEA NKSPSSSSSS SASSSSESAS SASDSDSSDS
     SSESSSEDSG SSSSSSQSSA SDKDRRKKGQ GNTRSKEVDK LIRKQQTHDR KQEERRPEQR
     HRETRTERER RSEKHKDKNS RDPNWRDPIT KYTSDRGVPS ERNSYSRIMN DRDQEAHTDL
     ENKYGDPKKK RGERRNSFSE NEHRHRNKDY ENVTRKDRSK SREKNRKHSG SRSDEDRYQN
     GAERRWEKSS RYSKQSRESN KHQDWRREKS PTKQKK
//