ID A0A2Y9J462_ENHLU Unreviewed; 656 AA.
AC A0A2Y9J462;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Vascular cell adhesion protein 1 isoform X3 {ECO:0000313|RefSeq:XP_022352845.1};
GN Name=LOC111143412 {ECO:0000313|RefSeq:XP_022352845.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022352845.1};
RN [1] {ECO:0000313|RefSeq:XP_022352845.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022352845.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
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DR RefSeq; XP_022352845.1; XM_022497137.1.
DR AlphaFoldDB; A0A2Y9J462; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd07689; IgC2_VCAM-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR047012; ICAM_VCAM.
DR InterPro; IPR003987; ICAM_VCAM_N.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008424; Ig_C2-set.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR003989; VCAM-1.
DR PANTHER; PTHR13771; INTERCELLULAR ADHESION MOLECULE; 1.
DR PANTHER; PTHR13771:SF14; VASCULAR CELL ADHESION PROTEIN 1; 1.
DR Pfam; PF05790; C2-set; 2.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 2.
DR PRINTS; PR01472; ICAMVCAM1.
DR PRINTS; PR01474; VCAM1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 617..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..114
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 232..318
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 428..512
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 517..601
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 656 AA; 72424 MW; 56A0570D587DBDFD CRC64;
MFSSQQKLKM PRKMVVIFGA SNVLWMVFAV SQAFKMEIFP EHRVIAQIGD VISLTCSTTG
CEPPSFSWRT QIDSPLNGKV RNEGNSSTLT MDPVSFNNEH AYVCTATCGS KKLEKGIQVE
IYSFPKDPEI HLSGPLELGK PVTVTCMVPD VYPFDRLEVN LMKDNELLKN KEFLEPMERK
SLETKSLAAT FIPTNEDIGK ALVCQAKLNI DEFDFEPKER ETTKKLQVYI SPKNTVISAS
PSTKLQEGGS VTMTCSSEGL PAPQIFWSKK LDNGNVQLLS GNATLTLIAM RIEDSGIYVC
EGVNQVGKDG KEVELIVQAF PRDPEIEMSG LLVSGNPVTV SCEVPNVYPS DRLEIELFKG
ESIIESKTFL EDMDKKSLET KSLDMTFIPT TEDTGKVLVC LAQLHIGEME FEPKQRQSTQ
MLHVNVAPRD TTILVSPSSI LEEGSSVNMT CSSNGLPAPK ILWSRQLNNG DLQPLSENST
LALTSTKMDD SGIYVCEGIN QAGISRKEVE LIIQVAPKDI QLIAFPSESV KEGDTVIISC
TCGNVPKTWI ILKKKAETGD TVLKSRDGAY TIHKVQLEDA GVYECESKNE VGLQLRSLTL
DVKGRENNKD YFSPELLVLY CASSLIIPAI GMIIYFARRA NMKGSYSLVE AQKSKV
//
