ID   A0A2Y9J5Y8_ENHLU        Unreviewed;      1001 AA.
AC   A0A2Y9J5Y8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=General transcription factor II-I isoform X2 {ECO:0000313|RefSeq:XP_022356378.1};
GN   Name=LOC111145631 {ECO:0000313|RefSeq:XP_022356378.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022356378.1};
RN   [1] {ECO:0000313|RefSeq:XP_022356378.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022356378.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_022356378.1; XM_022500670.1.
DR   AlphaFoldDB; A0A2Y9J5Y8; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 3.90.1460.10; GTF2I-like; 6.
DR   InterPro; IPR004212; GTF2I.
DR   InterPro; IPR036647; GTF2I-like_rpt_sf.
DR   InterPro; IPR016659; TF_II-I.
DR   PANTHER; PTHR46304:SF2; GENERAL TRANSCRIPTION FACTOR II-I; 1.
DR   PANTHER; PTHR46304; GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF02946; GTF2I; 6.
DR   PIRSF; PIRSF016441; TF_II-I; 1.
DR   SUPFAM; SSF117773; GTF2I-like repeat; 6.
DR   PROSITE; PS51139; GTF2I; 6.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   REGION          207..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          661..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          686..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          815..836
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          959..1001
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        687..712
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        976..992
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1001 AA;  112647 MW;  6CE17CA3FF2FCD7B CRC64;
     MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE
     RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSVAPAN RMSVDAVEIE TLRKTVEDYF
     CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI
     SFIIKRPFLE PKKHLGGRVM VTDAERSMLS PGGSCGPVKV KTEPTEDSGI SLEMAAVTVK
     EESEDPDYYQ YNIQGPSETA DVDDKLPLSK SLQGSHHSSE GNEGTEMEVP AEDSTQHVPS
     ETSEDPEVEV TIEDDDYSPP TKRPKSSEPP QPPVAEPANA GKRKVREFNF EKWNARITDL
     RKQVEELFER KYAQAIKAKG PVTIPYPLFQ SHVEDLYVEG LPEGIPFRRP STYGIPRLER
     ILLAKERIRF VIKKHELLNS TREDLQLDKP ASGVKEEWYA RITKLRKMVD QLFCKKFAEA
     LGSTEAKAVP YQKFEAHPND LYVEGLPENI PFRSPSWYGI PRLEKIIQVG NRIKFVIKRP
     ELLTHSTTEV TQPRTNTPVK EDWNVRITKL RKQVEEIFNL KFAQALGLTE AVKVPYPVFE
     SNPEFLYVEG LPEGIPFRSP TWFGIPRLER IVRGSNKIKF VVKKPELVIS YLPPGMASKI
     NTKALQSPKR PRSPGSNSKV PEIEVTVEGP NNNNPQTSAV RTPTQTNGSN VPFKPRGREF
     SFEAWNAKIT DLKQKVENLF NEKCGEALGL KQAVKVPFAL FESFPEDFYV EGLPEGVPFR
     RPSTFGIPRL EKILRNKAKI KFIIKKPEMF ETAIKESTSS SKSPPRKINS SPNVNTTASG
     VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN
     PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQNESE
     GPVIQESAEP SQLEVPATEG KKEIKETDGN SQIKQEPDPT W
//