ID   A0A2Y9J631_ENHLU        Unreviewed;      1069 AA.
AC   A0A2Y9J631;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Rab GTPase-activating protein 1 {ECO:0000313|RefSeq:XP_022356428.1, ECO:0000313|RefSeq:XP_022356429.1};
GN   Name=LOC111145651 {ECO:0000313|RefSeq:XP_022356428.1,
GN   ECO:0000313|RefSeq:XP_022356429.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022356428.1};
RN   [1] {ECO:0000313|RefSeq:XP_022356428.1, ECO:0000313|RefSeq:XP_022356429.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022356428.1,
RC   ECO:0000313|RefSeq:XP_022356429.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_022356428.1; XM_022500720.1.
DR   RefSeq; XP_022356429.1; XM_022500721.1.
DR   STRING; 391180.A0A2Y9J631; -.
DR   KEGG; elk:111145651; -.
DR   OrthoDB; 2908929at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   CDD; cd01211; PTB_Rab6GAP; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR   Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR   Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR   InterPro; IPR022164; Kinesin-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
DR   InterPro; IPR035969; Rab-GAP_TBC_sf.
DR   PANTHER; PTHR47219:SF6; RAB GTPASE-ACTIVATING PROTEIN 1; 1.
DR   PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR   Pfam; PF12473; DUF3694; 1.
DR   Pfam; PF00640; PID; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR   PROSITE; PS01179; PID; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          152..267
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   DOMAIN          566..752
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000259|PROSITE:PS50086"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          800..922
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          989..1041
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        9..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..508
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1069 AA;  121603 MW;  188A1C1BA3B180BD CRC64;
     MDDKASVGKI SVSSDSVSTL NSEDFVLVSR QGDETPSTNN GSDDEKTGLK IIGNGSEQQL
     QKELADVLMD PPMDDQPGDK ELVERSQLDG EGDGPLSNQL SASSTINPVP LVGLQKPEMS
     LPVKPGQGDS EGSSPFTPAA DEDSVVFSKL TYLGCASVNA PRSEVEALRM MSILRSQCQI
     SLDVTLSVPN VSEGTVRLLD PQTNTEIANY PIYKILFCVR GHDGTPESDC FAFTESHYNA
     ELFRIHVFRC EIQEAVSRIL YSFATAFRRS AKQTPLSAAA APQTPDSDIF TFSVSLEIKE
     DDGKGYFSAV PKEKDRQCFK LRQGTDKKIV IYVQQTTNKE LAIERCFGLL LSPGKDVRNS
     DMHLLDLESM GKSSDGKSYV ITGSWNPKSL PFQVVNEETP KDKVLFMTTA VDLVITEVQE
     PVRFLIETKV RVCSPNERLF WPFSKRSTTE NFFLKLKQIK QKERKNNTDT LYEVVCLESE
     SERERRKTTA SPSIRLPQSG SQSSMIPSPP EDDEEEDNDE PLLSGFGDVS KECAGKILET
     WGELLSKWHL NLSVRPKQLS SLVRSGVPEA LRGEVWQLLA GCHNNDHLVE KYRILITKES
     PQDSAITRDI NRTFPAHDYF KDTGGDGQDS LYKICKAYSV YDEEIGYCQG QSFLAAVLLL
     HMPEEQAFSV LVKIMFDYGL RELFKQNFED LHCKFYQLER LMQEYIPDLY NHFLDISLEA
     HMYASQWFLT LFTAKFPLYM VFHIIDLLLC EGISVIFNVA LGLLKTSKDD LLLTDFEGAL
     KFFRVQLPKR YRSEENAKKL MELACSMKIS QKKLKKYEKE YHTMREQQAQ QEDPIERFER
     ENRRLQEANM RLEQENDDLA HELVTSKIAL RKDLDNAEEK ADALNKELLM TKQKLIDAEE
     EKRRLEDESA QLKEMCRREL DKAESEIRKN SSIIGDYKQI CSQLSERLEK QQTANKVEIE
     KIWQKVDDCE RCREFFNKEG RIKGMSSAKE VLDEDTDEEK ETLKNQLREM ELELAQTKLQ
     LVEAECKIQD LEHHLGLALN EVQAAKKTWF NRTLSSIKTA TGVQGKETC
//