ID A0A2Y9J6H5_ENHLU Unreviewed; 735 AA.
AC A0A2Y9J6H5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=LOW QUALITY PROTEIN: forkhead box protein K1 {ECO:0000313|RefSeq:XP_022356578.1};
GN Name=LOC111145719 {ECO:0000313|RefSeq:XP_022356578.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022356578.1};
RN [1] {ECO:0000313|RefSeq:XP_022356578.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022356578.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_022356578.1; XM_022500870.1.
DR AlphaFoldDB; A0A2Y9J6H5; -.
DR STRING; 391180.A0A2Y9J6H5; -.
DR KEGG; elk:111145719; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd20054; FH_FOXK1; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047394; FH_FOXK1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45881; CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR45881:SF4; FORKHEAD BOX PROTEIN K1; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 127..179
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 309..404
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 309..404
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 38..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..73
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 735 AA; 75804 MW; F8B5CD86914CA3B0 CRC64;
MAEVGEDSGA RALLALRSAP CSPVLCAAAA AAAAFPAAAA PAAPAPGPPP SPPPPAQPPP
PPPPPPPPPL PGAIAGSAGA AGAGGAIAGA AEALVAAAAA SVRRSPGPAL ARLEGREFEF
LMRQPSVTIG RNSSQGSVDL SMGLSSFISR RHLQLTFQEP HFYLRCLGKN GVFVDGAFQR
RGAPALQLPK QCTFRFPSTA IKIQFTSLYR PEEAPASPLR PLYPQISPLK IHIPEPDLRS
LVSPVPSPTG TISVPNSCPA SPRGAGSSSY RFVQNVTSDL QLAAEFAAKA ASEQQADTSG
GDSPKDESKP PYSYAQLIVQ AISSAQDRQL TLSGIYAHIT KHYPYYRTAD KGWQNSIRHN
LSLNRYFIKV PRSQEEPGKG SFWRIDPASE AKLVEQAFRK RRQRGVSCFR TPFGPLSSRS
APASPTHPGL MSPRSSGLQT PECLSREGSP IPHDPDFGSK LASVPEYRYS QSAPGSPVSA
QPVIMAVPPR PPSLVAKPVA YMPASIVTAQ QPSGHAIHVV QQAPPVTMLR VVTTSASSAN
GYILASQASA GGAHEAAGTA VLDLGSEARG LEEKPAVAFA AVPTTSRVIQ TVASQMAPGV
PGHTVTILQP ATPVTLGQHH LPVRAVTQNG KHAVPTNSLA SSTYALTSPL QLLAAQASSS
TPVVVTRVCE VGPEEPAAVA ATPATPATPA TAATSASSTG EPEVKRSRVE EPSGTVTAQA
GVIAAAGPQG PGTGE
//
