ID A0A2Y9J7H9_ENHLU Unreviewed; 255 AA.
AC A0A2Y9J7H9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=T-cell-specific surface glycoprotein CD28 {ECO:0000256|ARBA:ARBA00015051};
GN Name=LOC111144043 {ECO:0000313|RefSeq:XP_022353830.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022353830.1};
RN [1] {ECO:0000313|RefSeq:XP_022353830.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022353830.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_022353830.1; XM_022498122.1.
DR AlphaFoldDB; A0A2Y9J7H9; -.
DR STRING; 391180.A0A2Y9J7H9; -.
DR KEGG; elk:111144043; -.
DR OrthoDB; 4108912at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0042129; P:regulation of T cell proliferation; IEA:InterPro.
DR CDD; cd20925; IgV_CD28; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR008093; CD28.
DR InterPro; IPR040216; CTLA4/CD28.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11494; CYTOTOXIC T-LYMPHOCYTE PROTEIN; 1.
DR PANTHER; PTHR11494:SF7; T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28; 1.
DR Pfam; PF15910; V-set_2; 1.
DR PRINTS; PR01717; CD28ANTIGEN.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 188..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..149
FT /note="Immunoglobulin V-set"
FT /evidence="ECO:0000259|SMART:SM00406"
SQ SEQUENCE 255 AA; 29243 MW; 64165D845CD4911E CRC64;
MTETLRLQQV HLLFPSHSGL LGEEGLEPWP TISTMILRLL LALNFFPSIQ VAENKILVKQ
LPMLVVYNNE VNLSCKYTHN LFSKEFRASL YKGVDSAVEV CVVNGNYSHQ PQFYSSTGFD
CDGKLGNETV TFYLRKLFVN QTDIYFCKIE VMYPPPYIDN EKSNGTIIHV KEKHLCPVQP
SPQSSKPFWA LVVVCGVLVF YSLLVTVALC ACWMKSRRNR ILQSDYMNMT PRRPGPTRRH
YQPYAPARDF AAYRS
//
