ID A0A2Y9J7U8_ENHLU Unreviewed; 1916 AA.
AC A0A2Y9J7U8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Dedicator of cytokinesis protein 10 isoform X3 {ECO:0000313|RefSeq:XP_022355769.1};
GN Name=LOC111145251 {ECO:0000313|RefSeq:XP_022355769.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022355769.1};
RN [1] {ECO:0000313|RefSeq:XP_022355769.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022355769.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_022355769.1; XM_022500061.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11699; DHR2_DOCK10; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 2.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 1..29
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 411..589
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1420..1880
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1020..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1916 AA; 219001 MW; 8EABB7843F216252 CRC64;
MNDLTYFVLA AETESDMDEW IHTLNRILQI SPEGPSQGRR STELAELGLD SLDNSITCEC
TPEETESSEN NLHPDFAKYL TETEETVKTT RNMERLNLFS LDPDIDTLKL QKKDLLEPDS
VIKPFEEKAA KRIMIICKAL NLNLQGCVTE NENDPITNIE PFFVSVALYD LRNSRKISAD
FHVDLNHTAV RQMLSGSSVA LENGNIDTVT PRQSEEPHIK GFPEEWLRFP KQAIFSVSNP
HSEIVFVAKI EKVLMGNIAN GAEPYIKNPD SNKYAQKILK SNRQFFSKLG KYRMPFAWAV
RSVFKDNQGN VDRDSRFSPL YRQESSKIST EDLLKLVSDY RRADRVSKTQ TIPGSLDIAV
DNIPLEHPNC VTSSFIPVKP FDVTAQLEPT VEVEEFIYDS TKYCRPYRVY KNQIYIYPRH
LKYDSQKCFN KARNITVCIE FKNSDEEGAK PVKCIYGKPG GPLFTSAAHT AVLHHSQNPD
FSDEVKIELP TQLHEKHHIL FSFYHVTCDI NAKANAKKKE TLETSVGYAW LPLMKHDQIA
SQEYNIPIAT SLPPNYLSFQ DSASGKHGGG DIKWVDGGKP LFKVSTFVVS TVNTQDPRVN
AFFRQCQKRE KDMSQSPTSN FIRSCKNLLN VEKIHAIMSF LPIILNQLFK VLVQNEEDEI
STTVTRVLTD IVAKCHEEQL EHSVQSYIKF VFKTTACKER TIHEELAKNV TGLLKSNDST
TVKHVLKHSW FFFAIILKSM AQHLIDTNKI QLSRTQRFPE SYQNELDNLV MVLCDHVIWK
YKDALEETRR ANHSVARFLK RCFTFMDRGF VFKMVNNYVS MFSSGDLKTL CQYKFDFLQE
VCQHEHFIPL CLPIRSANIP DPLTPSESTQ ELHASDMPEY SVTNEFCRKH FLIGILLREV
GFALQEDQDI RHLALAVLKN LMAKHSFDDR YKQPEKQAQI ASLYMPLYGM LLDNMPRIYL
KDLYPFTVNT SNQGSRDDLS TNGGFHIQSA MKHANSVDTS FSKDVLNSIA VNHADSRASL
ASLDSNPSTN EKSSEKTDNC EKVPRPLSLI GSTLRFDKLD QAETRSLLMC FLHIMKTISE
ETLIAYWQRA PSPEISDFFS ILDVCLQNFR YLGKRNIIRK IAAAFKFVQS TQNNGTLKGS
NPSCQASGPL SQWMHTPSTH EGHKQHRSQT LPIIRGKNAL SNPKLLQMLD NTISSNSNEI
DIVHHVDTEA NIATEVCLTI LDLLSLFTQI HQRQLQQSEC QNSMMKRVFD TYMLFFQVNQ
SATALKHVFA SLRLFVCKFP SAFFQGPADL CGSFCYEVLK CCNHRSRSTQ TEASALLYFF
MRKNFEFNKQ KSIVRSHLQL IKAVSQLIAD AGIGGSRFQH SLAITNNFAN GDKQMKNSNF
PAEVKDLTKR IRTVLMATAQ MKEHEKDPEM LVDLQYSLAN SYASTPELRR TWLESMAKIH
ARNGDLSEAA MCYIHIAALI AEYLKRKGYW KMEKICTPPL LPEDIHPCDS YPLLTAPGGG
SMFSMGWPAF LSITPNIKEE GAMKEDSGMQ DTPYNENILV EQLYLCVEFL WKSERYELIA
DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY LKVAEVVNSE KRLFGRYYRV AFYGQGFFEE
EEGKEYIYKE PKLTGLSEIS QRLLKLYADK FGADNVKIIQ DSNKVNPKDL DPKYAYIQVT
YVTPFFEEKE IEDRKTDFEM HHNINRFVFE TPFTLSGKKH GGVEEQCKRR TVLTTSHLFP
YVKKRIQVIS QSSTELNPIE VAIDEMSKKV SELNQLCTMD DVDMIRLQLK VQGSVSVKVN
AGPMAYARAF LEETNAKRYP DNQVKLLKEI FRQFADACGQ ALDVNERLIK EDQLEYQEEL
RSHYKDMLSE LSAIMNEQIT YRDDPSKRGA ERTCPLVISR AAPAVPTVSI SASEEA
//