ID   A0A2Y9J7U8_ENHLU        Unreviewed;      1916 AA.
AC   A0A2Y9J7U8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Dedicator of cytokinesis protein 10 isoform X3 {ECO:0000313|RefSeq:XP_022355769.1};
GN   Name=LOC111145251 {ECO:0000313|RefSeq:XP_022355769.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022355769.1};
RN   [1] {ECO:0000313|RefSeq:XP_022355769.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022355769.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00983}.
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DR   RefSeq; XP_022355769.1; XM_022500061.1.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd08697; C2_Dock-D; 1.
DR   CDD; cd11699; DHR2_DOCK10; 1.
DR   Gene3D; 1.20.58.740; -; 1.
DR   Gene3D; 1.25.40.410; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR037809; C2_Dock-D.
DR   InterPro; IPR027007; C2_DOCK-type_domain.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR026791; DOCK.
DR   InterPro; IPR043161; DOCK_C_lobe_A.
DR   InterPro; IPR043162; DOCK_C_lobe_C.
DR   InterPro; IPR027357; DOCKER_dom.
DR   InterPro; IPR046769; DOCKER_Lobe_A.
DR   InterPro; IPR046770; DOCKER_Lobe_B.
DR   InterPro; IPR046773; DOCKER_Lobe_C.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR   PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR   Pfam; PF06920; DHR-2_Lobe_A; 2.
DR   Pfam; PF20422; DHR-2_Lobe_B; 1.
DR   Pfam; PF20421; DHR-2_Lobe_C; 1.
DR   Pfam; PF14429; DOCK-C2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS51650; C2_DOCK; 1.
DR   PROSITE; PS51651; DOCKER; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          1..29
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          411..589
FT                   /note="C2 DOCK-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51650"
FT   DOMAIN          1420..1880
FT                   /note="DOCKER"
FT                   /evidence="ECO:0000259|PROSITE:PS51651"
FT   REGION          1020..1042
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1136..1168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1136..1158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1916 AA;  219001 MW;  8EABB7843F216252 CRC64;
     MNDLTYFVLA AETESDMDEW IHTLNRILQI SPEGPSQGRR STELAELGLD SLDNSITCEC
     TPEETESSEN NLHPDFAKYL TETEETVKTT RNMERLNLFS LDPDIDTLKL QKKDLLEPDS
     VIKPFEEKAA KRIMIICKAL NLNLQGCVTE NENDPITNIE PFFVSVALYD LRNSRKISAD
     FHVDLNHTAV RQMLSGSSVA LENGNIDTVT PRQSEEPHIK GFPEEWLRFP KQAIFSVSNP
     HSEIVFVAKI EKVLMGNIAN GAEPYIKNPD SNKYAQKILK SNRQFFSKLG KYRMPFAWAV
     RSVFKDNQGN VDRDSRFSPL YRQESSKIST EDLLKLVSDY RRADRVSKTQ TIPGSLDIAV
     DNIPLEHPNC VTSSFIPVKP FDVTAQLEPT VEVEEFIYDS TKYCRPYRVY KNQIYIYPRH
     LKYDSQKCFN KARNITVCIE FKNSDEEGAK PVKCIYGKPG GPLFTSAAHT AVLHHSQNPD
     FSDEVKIELP TQLHEKHHIL FSFYHVTCDI NAKANAKKKE TLETSVGYAW LPLMKHDQIA
     SQEYNIPIAT SLPPNYLSFQ DSASGKHGGG DIKWVDGGKP LFKVSTFVVS TVNTQDPRVN
     AFFRQCQKRE KDMSQSPTSN FIRSCKNLLN VEKIHAIMSF LPIILNQLFK VLVQNEEDEI
     STTVTRVLTD IVAKCHEEQL EHSVQSYIKF VFKTTACKER TIHEELAKNV TGLLKSNDST
     TVKHVLKHSW FFFAIILKSM AQHLIDTNKI QLSRTQRFPE SYQNELDNLV MVLCDHVIWK
     YKDALEETRR ANHSVARFLK RCFTFMDRGF VFKMVNNYVS MFSSGDLKTL CQYKFDFLQE
     VCQHEHFIPL CLPIRSANIP DPLTPSESTQ ELHASDMPEY SVTNEFCRKH FLIGILLREV
     GFALQEDQDI RHLALAVLKN LMAKHSFDDR YKQPEKQAQI ASLYMPLYGM LLDNMPRIYL
     KDLYPFTVNT SNQGSRDDLS TNGGFHIQSA MKHANSVDTS FSKDVLNSIA VNHADSRASL
     ASLDSNPSTN EKSSEKTDNC EKVPRPLSLI GSTLRFDKLD QAETRSLLMC FLHIMKTISE
     ETLIAYWQRA PSPEISDFFS ILDVCLQNFR YLGKRNIIRK IAAAFKFVQS TQNNGTLKGS
     NPSCQASGPL SQWMHTPSTH EGHKQHRSQT LPIIRGKNAL SNPKLLQMLD NTISSNSNEI
     DIVHHVDTEA NIATEVCLTI LDLLSLFTQI HQRQLQQSEC QNSMMKRVFD TYMLFFQVNQ
     SATALKHVFA SLRLFVCKFP SAFFQGPADL CGSFCYEVLK CCNHRSRSTQ TEASALLYFF
     MRKNFEFNKQ KSIVRSHLQL IKAVSQLIAD AGIGGSRFQH SLAITNNFAN GDKQMKNSNF
     PAEVKDLTKR IRTVLMATAQ MKEHEKDPEM LVDLQYSLAN SYASTPELRR TWLESMAKIH
     ARNGDLSEAA MCYIHIAALI AEYLKRKGYW KMEKICTPPL LPEDIHPCDS YPLLTAPGGG
     SMFSMGWPAF LSITPNIKEE GAMKEDSGMQ DTPYNENILV EQLYLCVEFL WKSERYELIA
     DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY LKVAEVVNSE KRLFGRYYRV AFYGQGFFEE
     EEGKEYIYKE PKLTGLSEIS QRLLKLYADK FGADNVKIIQ DSNKVNPKDL DPKYAYIQVT
     YVTPFFEEKE IEDRKTDFEM HHNINRFVFE TPFTLSGKKH GGVEEQCKRR TVLTTSHLFP
     YVKKRIQVIS QSSTELNPIE VAIDEMSKKV SELNQLCTMD DVDMIRLQLK VQGSVSVKVN
     AGPMAYARAF LEETNAKRYP DNQVKLLKEI FRQFADACGQ ALDVNERLIK EDQLEYQEEL
     RSHYKDMLSE LSAIMNEQIT YRDDPSKRGA ERTCPLVISR AAPAVPTVSI SASEEA
//