ID A0A2Y9J9A8_ENHLU Unreviewed; 283 AA.
AC A0A2Y9J9A8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Guanine nucleotide-binding protein subunit alpha-12 isoform X3 {ECO:0000313|RefSeq:XP_022357191.1};
GN Name=LOC111146098 {ECO:0000313|RefSeq:XP_022357191.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022357191.1};
RN [1] {ECO:0000313|RefSeq:XP_022357191.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022357191.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(12) subfamily.
CC {ECO:0000256|ARBA:ARBA00010405}.
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DR RefSeq; XP_022357191.1; XM_022501483.1.
DR AlphaFoldDB; A0A2Y9J9A8; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000469; Gprotein_alpha_12/13.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF130; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-12; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00440; GPROTEINA12.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 283 AA; 33290 MW; 1224353B49DF4A2A CRC64;
MKFWEGSRVL VDARDKLGIP WQYSENEKHG MFLLAFENKA GLPVEPATFQ LYVPALSALW
RDSGIREAFS RRSEFQLGES VKYFLDNLDR IGQLNYFPSK QDILLARKAT KGIVEHDFVI
KKIPFKMVDV GGQRSQRQKW FQCFDGITSI LFMVSSSEFD QVLMEDRRTN RLVESMNIFE
TIVNNKLFFN VSIILFLNKM DLLVEKVKTV SIKKHFPDFK GDPHRLEDVQ RFLVQGFDRK
RRNRSRPLFH HFTTAIDTEN IRFVFHAVKD TILQENLKDI MLQ
//
