ID A0A2Y9J9K0_ENHLU Unreviewed; 598 AA.
AC A0A2Y9J9K0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X1 {ECO:0000313|RefSeq:XP_022357280.1, ECO:0000313|RefSeq:XP_022357281.1};
GN Name=LOC111146150 {ECO:0000313|RefSeq:XP_022357280.1,
GN ECO:0000313|RefSeq:XP_022357281.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022357281.1};
RN [1] {ECO:0000313|RefSeq:XP_022357280.1, ECO:0000313|RefSeq:XP_022357281.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022357280.1,
RC ECO:0000313|RefSeq:XP_022357281.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022357280.1; XM_022501572.1.
DR RefSeq; XP_022357281.1; XM_022501573.1.
DR STRING; 391180.A0A2Y9J9K0; -.
DR KEGG; elk:111146150; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13310; PH_RalGPS1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF167; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 50..289
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 459..571
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 289..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 66758 MW; C005D68A748D6BAC CRC64;
MYKRNGLMAS VLVTSATPQG SSSSDSLEGQ SCDYASKSYD AVVFDVLKVS PEEFASQITL
MDIPVFKAIQ PEELASCGWS KKEKHSLAPN VVAFTRRFNQ VSFWVVREIL TAQTLKIRAE
ILSHFVKIAK KLLELNNLHS LMSVVSALQS APIFRLTKTW ALLNRKDKTT FEKLDYLMSK
EDNYKRTREY IRSLKMVPSI PYLGIYLLDL IYIDSAYPAS GSIMENEQRS NQMNNILRII
ADLQVSCSYD HLTTLPHVQK YLKSVRYIEE LQKFVEDDNY KLSLRIEPGS SSPRLVSSKE
DLAGPSAGSS SARFSRRPTC PDASVAGSLP TPPVPRHRKS HSLGNNMMCQ LSVVESKSAT
FPSEKARHLL DDSVLESRSP RRALALTSSS AVTNGLSLGS SESSEFSEEM SSGLESRGRL
YATLGPNWRV PVRNSPRTRS CVYSPTGPCI CTLGSSATVP TMEGPLRRKT LLKEGRRPAL
SSWTRYWVIL SGSTLLYYGA KSLRGTDRKH YKSTPGKKVS VVGWMVQLPD DPEHPDIFQL
NNPDKGNVYK FQTGSRFHAI LWHKHLDDAC KSNRPQVKSP KPCLSLETSS PTLRTKSP
//
