ID A0A2Y9JAM3_ENHLU Unreviewed; 1371 AA.
AC A0A2Y9JAM3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Tonsoku-like protein {ECO:0000256|ARBA:ARBA00017829};
DE AltName: Full=NF-kappa-B inhibitor-like protein 2 {ECO:0000256|ARBA:ARBA00033240};
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 {ECO:0000256|ARBA:ARBA00030801};
GN Name=LOC111146696 {ECO:0000313|RefSeq:XP_022358072.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022358072.1};
RN [1] {ECO:0000313|RefSeq:XP_022358072.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022358072.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the Tonsoku family.
CC {ECO:0000256|ARBA:ARBA00010999}.
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DR RefSeq; XP_022358072.1; XM_022502364.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46358; TONSOKU-LIKE PROTEIN; 1.
DR PANTHER; PTHR46358:SF1; TONSOKU-LIKE PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF13176; TPR_7; 1.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00367; LRR_CC; 4.
DR SMART; SM00368; LRR_RI; 6.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803}.
FT REPEAT 525..557
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 558..590
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 594..626
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 448..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..491
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1371 AA; 149569 MW; 7A51187685D61070 CRC64;
MSVERELRQL SKAKAKAQRN GQLRDEAALC HQLGELLASH GRYAEALREH QHELQLLESV
DDPLGCAVAH RKIGERLAEL EDYSAALKHQ HRHLELARSL SNHTEVQRAW ATIGRTHLDI
YDHCQSQDTL VQAQTAFEKS LAIVDEKLQG TLDKRELSEM RTRLYLNLGL TFESLQQAAP
CDDYFRKSIF LAEQNHLHED LFRARYNLGA VHWRRGHHSR AMRCLEGARE CARVLRRGQM
ESECCVLISQ ILQDLGDFLA AKRALKKAYR LGFQTPLQKA AVCRTLKHVL AVVRLQQRLR
EAESSDPQGA MGICEQLGDL FSKAGDFPKA AEAYQKQLHL AELLGRPGPE LAVIHVSLAA
TLGDMKDHHR AVSHYEQELR LRGGDALEEA QTWLNIALSR EEAGDAYERL APCFQKALSC
AQQAQQPQLQ RQILQHLHAV QLRLRPQEAP ATAASLQELS SPREQEEDDE EEEEEDEATP
EPSDVELSES EGDSEGGSQR LEEDEELQGR LGQPRVNKWN RRNDVGETLL HRACIEGRLG
RVQDLVRQGH PLNPRDYCGW TPLHEACNYG HVDIVRFLLD HGAQVDDPGG PGCEGITPLH
DALHCGHFEV AQLLIERGAS VTLRTAKGHS PRETLQQWLK LYGKDLDSET REKAAAMERL
LRVASSGQAP HSSAAPHTPP RNHLFDPELS PPSSPGPGPS EPSQAHAGVS PGHAVPAMAR
PRRSRPKLAS SSSSEGEDSP GPCRPVHKRP RHRVPVQQAR AGAPGYPSGR EAEAASAARA
AIRGVAGAQI CRPGPSLLRG PGEPTTPRAA LIPEEECLAG DWLEDDSPLT RSCQDGSRPH
PQGSANSPGP RGSGSGRSKS PNGLRARARQ SRLPRLRSWN AAGRAGGDGS PAAEPPRSPD
LSRASGPCRD SPAAGQAPGP SLPPPIRVRV RVQDSLFLIP VPHGGETHSV AWLTEQAAQR
YCQACGLLPR LVLRKEGALL APQDPIPDVL QSNEEVLAEV TSWDLPPLTD RYRRACRSLE
QEEHPQVLQA MDRQGSSPSF SVGSLALRQT QLTPLLRALK LHTALRELHL AGNRLGDGCA
AELLAALGTM PSLMLLDLSS NHLGSEGLRH LAAGLQGQTT LQNLQELDLS MNPLGDGCGR
ALASILQGCP SLSTLHLQAC GFGPSFFLSH QAALGSAFQD AKHLKTLSLS YNILGPDALA
HALQNLPART LRRLELNSVA AGKSDSGLVE PVVRYLAKEG CTLAHLSLSA NHLGDKAVRD
LSRCLPCCPS LMSLDLSANP DVSCVGLEEL LSALQMRPQG LSFLGLSGCA VQGPLRLGLW
REITAQVQEL ELCSRRLSPD DRAALRQLLP GRPGPGACTL DRGSKLFFRR L
//
