ID A0A2Y9JAV8_ENHLU Unreviewed; 759 AA.
AC A0A2Y9JAV8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Metastasis suppressor protein 1 isoform X1 {ECO:0000313|RefSeq:XP_022358162.1};
GN Name=LOC111146777 {ECO:0000313|RefSeq:XP_022358162.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022358162.1};
RN [1] {ECO:0000313|RefSeq:XP_022358162.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022358162.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022358162.1; XM_022502454.1.
DR AlphaFoldDB; A0A2Y9JAV8; -.
DR STRING; 391180.A0A2Y9JAV8; -.
DR KEGG; elk:111146777; -.
DR OrthoDB; 3875239at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR CDD; cd07643; I-BAR_IMD_MIM; 1.
DR CDD; cd22060; WH2_MTSS1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR013606; I-BAR_dom.
DR InterPro; IPR030127; MTSS1/MTSS2.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR15708; ACTIN BUNDLING/MISSING IN METASTASIS-RELATED; 1.
DR PANTHER; PTHR15708:SF10; PROTEIN MTSS 1; 1.
DR Pfam; PF08397; IMD; 1.
DR Pfam; PF02205; WH2; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51338; IMD; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 1..254
FT /note="IMD"
FT /evidence="ECO:0000259|PROSITE:PS51338"
FT DOMAIN 731..748
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 259..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..638
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 82394 MW; 4676C125FFD47361 CRC64;
MEAVIEKECS ALGGLFQTII SDMKGSYPVW EDFINKAGKL QSQLRTTVVA AAAFLDAFQK
VADMATNTRG GTREIGSALT RMCMRHRSIE AKLRQFSSAL IDCLINPLQE QMEEWKKVAN
QLDKDHAKEY KKARQEIKKK SSDTLKLQKK AKKVDALGRG DIQPQLDSAL QDVNDKYLLL
EETEKQAVRK ALIEERGRFC TFISMLRPVI EEEISMLGEI THLQTISEDL KSLTMDPHKL
PSSSEQVILD LKGSDYSWSY QTPPSSPSTT MSRKSSVCSS LNSVNSSDSR SSGSHSHSPS
SHYRYRSSNL AQQAPVRLSS VSSHDSGFIS QDAFQSKSPS PMPPEAPNQL SNGFSHCSLP
SESHVGPVGA SLSPHCPPAS RLLPRVTSVH LPDFAHYHTI GPGMFPSSQI PSWKDWAKPG
PYDQPLVNTL QRRKEKREPD PNGGGPSAVG GAPAAAEEAQ RPRSMTVSAA NRPGEEMEAC
EELALALSRG LQLDTQRSSR DSLQCSSGYS TQTTTPCCSE DTIPSQVSDY DYFSVSGDQE
ADQQEFDKSS TIPRNSDISQ SYRRMFQAKR PASTAGLPTT LGPAVVTPGV ATIRRTPSTK
PSVRRGTIGA GPIPIKTPVI PVKTPTVPDL PGVLPAPPDG PEERGEHSPE LPSVGEGPQG
VTSMPSSMWS GQASVNPPLP GPKPSIPEEH RQAIPESEAE DQERDPSSAT ASPGRIPESD
AADLSPRDTP QGEDMLNAIR RGVKLKKTTT NDRSAPRFS
//
