ID A0A2Y9JBG0_ENHLU Unreviewed; 558 AA.
AC A0A2Y9JBG0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Poly(U)-binding-splicing factor PUF60 {ECO:0000256|ARBA:ARBA00018665};
DE AltName: Full=60 kDa poly(U)-binding-splicing factor {ECO:0000256|ARBA:ARBA00031478};
GN Name=LOC111146593 {ECO:0000313|RefSeq:XP_022357921.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022357921.1};
RN [1] {ECO:0000313|RefSeq:XP_022357921.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022357921.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM half pint family.
CC {ECO:0000256|ARBA:ARBA00005987}.
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DR RefSeq; XP_022357921.1; XM_022502213.1.
DR AlphaFoldDB; A0A2Y9JBG0; -.
DR STRING; 391180.A0A2Y9JBG0; -.
DR KEGG; elk:111146593; -.
DR OrthoDB; 12294at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12370; RRM1_PUF60; 1.
DR CDD; cd12371; RRM2_PUF60; 1.
DR CDD; cd12648; RRM3_UHM_PUF60; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR006532; PUF60-like.
DR InterPro; IPR034209; PUF60_RRM1.
DR InterPro; IPR034211; PUF60_RRM2.
DR InterPro; IPR034212; PUF60_RRM3.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR NCBIfam; TIGR01645; half-pint; 1.
DR PANTHER; PTHR47330:SF1; POLY(U)-BINDING-SPLICING FACTOR PUF60; 1.
DR PANTHER; PTHR47330; POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 3.
DR SMART; SM00361; RRM_1; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 3.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 128..206
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 225..303
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 461..548
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 11..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 558 AA; 59732 MW; C5A52C067CE7F88B CRC64;
MATATIALQV NGQQGGGSEP AAAAVAAAGD KWKPPQGTDS IKMENGQSTA AKLGLPPLTP
EQQEALQKAK KYAMEQSIKS VLVKQTIAHQ QQQLTNLQMA AVTMGFGDPL SPLQSMAAQR
QRALAIMCRV YVGSIYYELG EDTIRQAFAP FGPIKSIDMS WDSVTMKHKG FAFVEYEVPE
AAQLALEQMN SVMLGGRNIK VGRPSNIGQA QPIIDQLAEE ARAFNRIYVA SVHQDLSDDD
IKSVFEAFGK IKSCTLARDP TTGKHKGYGF IEYEKAQSSQ DAVSSMNLFD LGGQYLRVGK
AVTPPMPLLT PASPGGLPPA AAVAAAAATA KITAQEAVAG AAVLGTLATP GLVSPALTLA
QPLGALPQAV MAAQAPGVIT GVTPARPPIP VTIPSVGVVN PILASPPTLG LLEPKKEKEE
EELFPESERP EMLSEQEHMS ISGSSARHMV MQKLLRKQES TVMVLRNMVD PKDIDDDLEG
EVTEECGKFG AVNRVIIYQE KQGEEEDAEI IVKIFVEFSV ASETHKAIQA LNGRWFAGRK
VVAEVYDQER FDNSDLSA
//
