ID   A0A2Y9JBQ5_ENHLU        Unreviewed;      1236 AA.
AC   A0A2Y9JBQ5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=TBC1 domain family member 4 isoform X4 {ECO:0000313|RefSeq:XP_022358458.1};
GN   Name=LOC111146968 {ECO:0000313|RefSeq:XP_022358458.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022358458.1};
RN   [1] {ECO:0000313|RefSeq:XP_022358458.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022358458.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_022358458.1; XM_022502750.1.
DR   AlphaFoldDB; A0A2Y9JBQ5; -.
DR   Proteomes; UP000248482; Unplaced.
DR   CDD; cd01269; PTB_TBC1D1_like; 1.
DR   Gene3D; 1.10.10.2750; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR   Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR   InterPro; IPR021785; DUF3350.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
DR   InterPro; IPR035969; Rab-GAP_TBC_sf.
DR   PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR   PANTHER; PTHR47219:SF13; TBC1 DOMAIN FAMILY MEMBER 4 ISOFORM X1; 1.
DR   Pfam; PF11830; DUF3350; 1.
DR   Pfam; PF00640; PID; 2.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00462; PTB; 2.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR   PROSITE; PS01179; PID; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          118..195
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   DOMAIN          368..440
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   DOMAIN          856..1050
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000259|PROSITE:PS50086"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          587..705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          791..818
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1137..1206
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..27
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        685..703
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1236 AA;  139404 MW;  8DF9BCF3569F7B4E CRC64;
     MEPPSCIQDE PFPHPLEPEP GAPAQPGPGK PGDKRFRLWY VGGSCLDRRT TLPMLPWLMA
     EIRRRSQKPE AGGCGAPAAR EVLLVLSAPF LRCVPAPGVG AAGGVGPAAA QPNPAVFIFE
     HKAQHISRFI HNSHDLTYFA YLIKAQPDDP ESQMACHVFR ATDPNQVPDV ISSIRQLSKV
     AMKEDAKASK DNEDAFYNSQ KFEVLYCGKV TVTHKKAPLS LIDDCMEKFS LHEQQRLKIQ
     GEQCGADAGD DPGVFEATAP CSASDILSEE GDGVPDILPT LPATASQPGL PSSRAGFPER
     ILEDSGFDEQ QEFRSRCSSV TGVLQRKVHE NSQKPLPRRR HASAPSHVQP SDSEKNRTML
     FQVGRFEINL ISPDTKSVVL EKNFKDISSC SQGVKHVDHF GFICRESAEP GLGQYICYVF
     QCASESLVDE VMLTLRQAFS TAAALQSAKT QIKLCEACPM HSLHKLCERI EGLYPPRAKL
     VIQRHLSSLT DNEQADIFER VQKMKPISDQ EENELVILHL RQLCEAKQKT HIHIGEGPST
     ISNSTIPENA TSSGRFKLDI LKNKAKRSLT SSLENIFSRG ANRMRGRLGS MDSFERSNSL
     ASEKDYSPGD SPPGTPPASP LSSAWQTFPE EDSDSPQFRR RAHTFSHPPS STKRKLNLQD
     GRAHGVRSPL LRQSSSEQCS DGEGRKRTSS TCSNESLNAG GTPVTPRRIS WRQRIFLRVA
     SPMNKSPSAM QQDGLDRNEL LPLSPLAPTM EEEPLVIFMS GEDDPEKAEE RKKSEELRSL
     WKKAIHQQIL LLRMEKENQK LEASRDELQS RKVKLDYEEV GVCQKEVLIT WDKKLLNCRA
     KIRCDMEDIH VSLKEGVPKS RRGEIWQFLA LQYRLRHRLP NRQQPPDISY KELLKQLTAQ
     QHAILVDLGR TFPTHPYFSA QLGAGQLSLF NLLKAYSLLD QEVGYCQGIS FVAGVLLLHM
     SEEQAFEMLK FLMYDQGFRK QYRPDMMSLQ IQMYQLSRLL HDYHRDLYNH LEENEISPSL
     YAAPWFLTLF ASQFPLGFVA RVFDIIFLQG TEVIFKVALS LLSSQETLIM ECENFESIVE
     FLKTTLPDMN TSEMEKIITQ VFEMDISKQL HAYEVEYHVL QDELQESSYA YEESEPVEKL
     ERANSQLKRQ NMDLLEKLQI AHAKIQTLES NLENLLTRET KMKSLIRTLE QEKMVYQKTV
     DQIRKLLPAD ALANCEPLLR DLNGNPNNKA KTGNKP
//