ID A0A2Y9JBT6_ENHLU Unreviewed; 1052 AA.
AC A0A2Y9JBT6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=TSC22 domain family protein 1 {ECO:0000256|ARBA:ARBA00039911};
GN Name=LOC111146977 {ECO:0000313|RefSeq:XP_022358488.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022358488.1};
RN [1] {ECO:0000313|RefSeq:XP_022358488.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022358488.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family.
CC {ECO:0000256|ARBA:ARBA00007908}.
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DR RefSeq; XP_022358488.1; XM_022502780.1.
DR AlphaFoldDB; A0A2Y9JBT6; -.
DR STRING; 391180.A0A2Y9JBT6; -.
DR KEGG; elk:111146977; -.
DR OrthoDB; 2965073at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd21938; ZIP_TSC22D1; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000580; TSC22/Bun.
DR InterPro; IPR047862; TSC22/BUN_CS.
DR PANTHER; PTHR46745; TSC22 DOMAIN FAMILY PROTEIN 1; 1.
DR PANTHER; PTHR46745:SF1; TSC22 DOMAIN FAMILY PROTEIN 1; 1.
DR Pfam; PF01166; TSC22; 1.
DR SUPFAM; SSF58026; Delta-sleep-inducing peptide immunoreactive peptide; 1.
DR PROSITE; PS01289; TSC22; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 975..1009
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 34..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..83
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..239
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..606
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1052 AA; 106808 MW; B6CAF12964E33996 CRC64;
MHQPPESTAA AAAADISARK MAHPAMFPRR GSGSGSASAL NAAGTGVGSS ATSSEDFPPP
SLLQPPPPAA SSTSGPQPPP PQSLNLLSQA QLQAQPLAPG GTQMKKKSGF QITSVTPAQI
SASISSNNSI AEDTESYDDL DESHTEDLSS SEILDVSLSR ATDLGEPERS SSEETLNNFQ
EAETPGAVSP NQPHLPQPHL PHLPQQNVVI NGNAHPHHLH HHHHIHHGHH LHHGHHHPSH
AGVASTSIPG GPPSSPVSRK LSATGSSDSV MPAAPTSAVS SGGSPASVMT NIRAPSTTGS
IGISSVTGTN TMNTVNITAV GSFNPSVTSS MLSNASVNAS NIPSAASVSV GPGVSSGVNV
NILSGMGNGT ISSSAVVSSA PNAAAGMTVG SVSSQQQQPT VNTSRFRVVK LDSSSEPFKK
GRWTCTEFYE KDNAAPAAEG VAMNKVVETV KQNPAEVTSE RESTSGSSVS SSVSTLSHYT
ESVGSGEMGA PTVVVQPQPP PTLQGMALQQ MDFSSSGPPS IAQSQITQVQ LQPQELSYPQ
KQGLQPVPLQ ATLSAATGIQ PPPVSVVGVT SALGQQPSIS SLAQPQLPYP QTAPPVQAPP
PGAPPQQLQY GQQQPAVSAQ MVPSHGKAVT QNPASEYVQQ PPILQTAMSS GQPGAAGVGA
GTAAMPTAQP QSIQLPVQPA AIQAQPAGAS GQPVGQAQAA VSVVPPGSQI ANIGQQASIP
TAVQGPSTQV TPSVIPQGAP PSSQIVPPAP AAIIHQGVQT SASSLPQQLV LAPQSTLLTV
PPQPQGVESV AQVSQPLPAV SPLPSASSIS VTNQVSSTGP SGMPSAPTNL VPPQNIAQTP
ATQNGNLVQS VSQPPLIATN INLPLAQQIP LSSTQFSAQS LAQAIGSQIE DARRPAEPSL
VGLPQTISGD SGGMSAVSDG SSSSLAASAS LFPLKVLPLT TPLVDGEDES SSGASVVAID
NKIEQAMDLV KSHLMYAVRE EVEVLKEQIK ELIEKNSQLE QENNLLKTLA SPEQLAQFQA
QLQTGSPPAT TQPQGTTQPP AQPASQGSGP TA
//
