ID   A0A2Y9JDG7_ENHLU        Unreviewed;       887 AA.
AC   A0A2Y9JDG7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=LOC111147370 {ECO:0000313|RefSeq:XP_022359082.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022359082.1};
RN   [1] {ECO:0000313|RefSeq:XP_022359082.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022359082.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   RefSeq; XP_022359082.1; XM_022503374.1.
DR   AlphaFoldDB; A0A2Y9JDG7; -.
DR   STRING; 391180.A0A2Y9JDG7; -.
DR   KEGG; elk:111147370; -.
DR   OrthoDB; 960at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          51..146
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          347..404
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          818..845
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        300..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   887 AA;  100933 MW;  6F687D9F54B53892 CRC64;
     MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMSYTQE PAIQKGFLLK
     KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE
     EHIYHLKVKS EEIFDEWVSK LRHHRMYRQN EIAMFPHEVN HYFPGSTVTD SASGVLDSIS
     SRKRSSISKQ NSIQTGSNLS FSCAGETRVP LWLQSSEDME KCSKDLAHCH AFLVEMSQLL
     QSMDVLHRTY SAPAINAIQG TAFESPKKEK RSHRRWRSRA IGKDTTGTLQ VPKPFSGPVR
     LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLYHIA HKVYFTLRSA FNTLSAEREK
     MKQLMEQDVS SPPSAQVIGL KHALSSALAQ NTDLKERLRR IHAESLLLDS PAAAKSGDSL
     AEENSRDDSR ALVHQLSNES RLSITDSLSE FFDAQEVLLS PSSSENEISE DDSYVSDISD
     NLSLDNLSND LENERQTLGP VLESGGEAKS KRRTCLPAPC PSASAVSLWN ILRNNIGKDL
     SKVAMPVELN EPLNTLQRLC EELEYSELLD KAAQIPNALE RMVYVAAFAV SAYASSYFRA
     GSKPFNPVLG ETYECIREDK GFQFFSEQVS HHPPISACHA ESGNFVFWQD VRWKNKFWGK
     SMEIVPIGTT HVTLPAFRDH FEWNKVTSCI HNILSGQRWI EHYGEIVIKN LNDDSCHCKV
     NFIKAKYWST NAREIEGTVF DKDGKVVHRL FGKWHESIYC GGSSSSTCVW RANPMPKGYE
     QYYGFTQFAL ELNEMDPLSK SLLPPTDTRF RPDQRFLEEG NIEEAEIQKQ RIEQLQRERR
     RVLEENCVEH QPRFFRKSSD DSWVSNGTYL ELRKDLGFSK LDHPVLW
//