ID A0A2Y9JE71_ENHLU Unreviewed; 4570 AA.
AC A0A2Y9JE71;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Plectin isoform X2 {ECO:0000313|RefSeq:XP_022357979.1};
GN Name=LOC111146639 {ECO:0000313|RefSeq:XP_022357979.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022357979.1};
RN [1] {ECO:0000313|RefSeq:XP_022357979.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022357979.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022357979.1; XM_022502271.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd21238; CH_PLEC_rpt2; 1.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 6.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF20; PLECTIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 19.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 31.
DR SMART; SM00150; SPEC; 5.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 7.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 68..171
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 184..289
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 827..884
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1504..1530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1680..1710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1795..1814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1979..2031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2083..2195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2554..2599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4266..4302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4497..4570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 780..810
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1121..1228
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1261..1315
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 16..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1683..1710
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2083..2171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2572..2599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4266..4298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4497..4551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4570 AA; 518217 MW; A0D88013BF2D888C CRC64;
MSGEIHEGRP VAEDANGGSS SPSPGDTLPW NLGKTQRTRR GGGGSGGNGS VLDPAERAVI
RIADERDRVQ KKTFTKWVNK HLIKAQRHIS DLYEDLRDGH NLISLLEVLS GDSLPREKGR
MRFHKLQNVQ IALDYLRHRQ VKLVNIRNDD IADGNPKLTL GLIWTIILHF QISDIQVSGQ
SEDMTAKEKL LLWSQRMVEG YQGLRCDNFT SSWRDGRLFN AIIHRHKPTL IDMNKVFRQT
NLENLDQAFS VAERDLGVTR LLDPEDVDVP QPDEKSIITY VSSLYDAMPR VPDVQDGVKA
NELQLRWQEY RELVLLLLQW VRHHTAAFEE RRFPSSFEEI EILWCQFLKF KETELPAKEA
DKNRSKGIFQ SLEGAVQVGQ LKVPPGYHPL DVEKEWGTLH VAILEREKQL RGEFERLECL
QRVVSKLQME AGLCEEQLNH ADALLQLDVR LLAVGKAPQR AAEVERDLDK ADGMIRLLFN
DVQTLKDGRH PQGEQMYRRV YRLHERLVAI RTEYNLRLKA GVAAPVTPVS AQTTQRRPEL
EDVTLRYLQD LLAWVEENQR RVDSAEWGGD LPSVEAQLGS HRGLHQSVEE FRAKIERARA
DEGQLAPAPR GAYRDCLGRL DLQYAKLLNS SKARLRWLES LHGFVAAATK ELMWLSEKEE
EEVGFDWGEH NSNMAAKKES YSALMRELEL REKKIKEIQS TGDRLLREGH PARPTVESFQ
AALQTQWSWT LQLCCCIETH LKENTAYFQF FSDVRETEEQ LRKLQETLRR KYTCDRSVTV
TRLEDLLQDA QDEKDQLNEY RAHLSGLAKR AKAIVQLRPR NLTQPMRGRV PLLAACDYKQ
TEVTVHKGDE CQLLGPAQPS HWKVLSSSGS EAAMPSVCFL VPPPNQEAQD AVTRLEAQHQ
ALVTLWHQLH VDMKSLLAWQ SLSRDLQLIR SWSLVTFRTL KPEEQRQALR SLELHYQAFL
RDSQDAGSFG PEDRLQAERD YGSCSRHYQQ LVQSAEQGAQ EESRCQRCIS ELKDIRLQLE
ACETRTVHRL RLPLDEDPAR ECAQRIAEQQ KAQAEVEGLG KGVARLSAEA KKVLALPEPS
PAAPTLRSEL ELTLGKLEQV RSLSAIYLEK LKTISLVIRS TQGAEEVLRA HEEQLKEAQA
VPATLPELEA TKAALKKLRG QAEAQQPVFD ALRDELRGAQ AVGERLQRQH GERDVEVERW
RERVAPLLER WQAVLSQADV RLRELEQLGR RLRYYRESAD PLDSWLRDAK QRQEQIQAVP
LADSRAVREQ LRQEKALLEE IEQHGEKVEE CQRLAKQYIN AIKDYELQLV TYKAQLEPVA
SPAKKPKVQS GSESVIQEYV DLRTRYSELT TLTSQYIKFI SETLRRMEEE ERLAEQQRAE
ERERLAEVEA ALEKQRQLAE AHAQAKAQAE REAQELQRRM QEEVARREEA AVDAQQQKRS
IQEELQHLRE SSEAEIQAKA RQVEAAERSR LRIEEEIRVV RLQLETTERQ RGGAEGELQA
LRARAEEAEA QKRQAQEEAE RLRRQVQDES QRKRQAEAEL ALRVKAEAEA AREKQRAVQA
LEELRLQAEE AERRLRQAEA ERARQVQVAL ETAQRSAEAE LQSKRASFAE KTAQLERTLQ
EEHVAVAQLR EEAERHAQQQ AEAERAREEA EQELERWRLK ANEALRLRLQ AEEVAQQKSL
AQAEAEKQKE EAEREARRRG KAEEQAVRQR ELAEQELEKQ RQLAEGTAQQ RLVAEQELIR
LRAETEQGEQ QRQLLEEELA RLQREAGAAT QKRQELEAEL AKVRAEMEVL LASKARAEEE
SRSTSEKSKQ RLEAEAGRFR ELAEEAARLR ALAEETKRQR QLAEEDAARQ RAEAERVLAE
KLAAISEATR LKTEAEIALK EKEAENERLR RLAEDEAFQR RRLEEQAAQH KADIEERLAQ
LRKASESELE RQKGLVEDTV RQRRQVEEEI LALKASFEKA AAGKAELELE LGRIRSHAED
TLRSKEQAEL EAARQRQLAA EEEHRRREAE ERVQKSLAAE EEAARQRRSA LEEVERLKAK
VEEARRLRER AEQESARQLQ LAQEAAQKRL QAEEKAHAFA VQRKEQELQQ TLQHEQSELE
RLRAEAEAAR RAAEEAEAAR ERAEREAAQS RQQVEEAERL KRSAEEQEQA RARAQAAAEK
LRKDAEQEAA RRAQAEQAAL KQKQVADAEM EKHKQFAERT LRQKAQVEQE LTALRLQLEE
TDHQKSILDE ELQRLKAEAT EAARQRSQVE EELFSVRVQM EELGKLKARI EAENRALILR
DKDNTQRFLQ EEAEKMKQVA EEAARLSVAA QEAARLRQLA EEDLAQQRAL AEKMRKEKMQ
AVQEATRLKA EAELLQQQKE QAQEQARQLR EDKEHMAQQL AQETQGFQRT LEAERQRQLE
MSAEAERLKM RVAEMSRAQA RAEEDAQRFR KQVEEIGEKL HRTELATQEK VTLVHTLEIQ
RQQSDQDAER LRAAIAELER EKEKLTEEAA LLQHKSEEMQ VVQQEQLLQE ARALQESFLS
EKDRLLQREH FVEEEKAKLE RLFQDEVAKA QKLREEQQRQ RQQMEQEKQQ LVASMEEARQ
RQREAEEGAR RQQEELQRLQ EQRRQQEELL AEENRRLRER LQRLEEEHRA AQVQSEEIAA
AQAMAAKALP NGRDAPDGPA AEAEPELAFD GLRRKVPAQR LQEVEVLSSE ELQRLAQGHT
TVAELAQRED VRRYLQGRSG VAGLLLKPTD EKLSIYAALQ RQLLSPGTAL ILLEAQAASG
FLLDPVCNRR LTVQEAVKEG VVGPELHHQL LSAERAVTGY TDPYTGEQIS LFQAMKKDLI
VRDHGLRLLE AQIATGGIID PVHSHRLPVD VAYRRGYFDE DMNRVLADPS DDTKGFFDPN
THENLTYLQL LERCVEDPET GLRLLPLTDQ AARGGELVYT DSEARDVFEK ATVSAPFGRF
QGRTVTIWEL INSEYFTAEQ RRDLLRQFRT GKVTVEKIIK MVITVVEEHE QKGQLCFEGL
RALVPAVELL ESGIIDRDLL RQLQRGERSV REVADVDAVR RALRGANVIA GVWLEEAGQK
VSIYEALKKD LLPPEAAVAL LEAQAGTGHV IDPATSARLT VDEAVRAGLV GPELHEKLLS
AEKAVTGYKD PYSGQSVSLF QALKKGLIPR EQGLRLLDAQ LATGGIVDPS KSHRVPVDVA
CARGYLDEET RRILSAPGKE ARTYCDPTSQ EPVTYGQLQQ QCRPDQLTGL SLLPVSEKAA
QARREGLCSE LQAQETFQKT PVEVPVGSFK GRTVTVWELL SSEYFTAEQR QELVRQFRTG
TVTVEKVIKI LITIVEEVET VRRERLSFSG LRAPVPASEL VASGVLSSTQ FEQLKDGRTS
VKDLSELSSV RTLLQGSGCL AGIYLESSKE KVTIYEAMRR GLLRPSTATL LLEAQAATGF
LVDPVRNQRL YVHEAVKAGV VGPELHEKLL SAEKAVTGYK DPYSGSTISL FQAMKKGLVL
RDHGLRLLEA QIATGGIIDP VHSHRLPVDV AYQRDYFDED MNRVLADPSD DTKGFFDPNT
HENLTYLQLL ERCVEDPETG LRLLPLRDAE RTEVVETTQV YTEEETRRAF EETQIDIPGG
GGRGGSTMSL WEVMQSDLIP EEQRARLLAD FQAGRVTKER VIVIIIEIIE KTEIIRQQNL
ASYDYVRRRL TAEDLHEARI ISHETYGLLR AGTKSLRQVL EEESASRYLY GTGCVAGVYL
PGSRQTLSVY QALKKGLLSA EVARLLLEAQ AATGFLLEPV KGERLTVDEA VRKGLVGPEL
HDRLLSAERA VTGYHDPYTE QTISLFQAMK KELIPTEEAL RLLDAQLATG GIVDPRLGFH
LPLEVAYQRG YLNKDTYEQL SEPSEVRSYL DPSTDERLSY TQLLRRCCRH ETSGQLLLPL
SDARKLTFRG LRKQITVEEL VRSQVMDEAT ALRLQEGLAS VEEVSRNLQK FLEGTSCIAG
VLVDATKERL SVYQAMKKGV IRPGTAFELL EAQAATGYVI DPIKGLKLTV EEAVRMGIVG
PEFKDKLLSA ERAVTGYKDP YSGKLISLFQ AMKKGLILKD HGIRLLEAQI ATGGIIDPEE
SHRLPVDVAY QRGLFDEEMN EILTDPSDDT KGFFDPNTEE NLTYLQLMER CVEDPGTGLR
LLPLKEKKRE RKTSSKSSVR KRRVVIVDPE TGKEMSVYEA YRKGLIDHQT YLELSEQECE
WEEITISSSD GVVKSMIIDR RSGRQYDIDE AIARNLIDRS ALDQYRAGTL SITEFADMLS
GNASGFRSRS SSVGSSSSYP VSPAPSRTQV TSWSDPTEET GPVAGILDTE TLEKVSITEA
MHRGLVDNIT GQRLLEAQAC TGGILDPSTG ERFPVMDAVN KGLVDKIMVD RINLAQKAFC
GFEDPRTKTK MSAAQALKKG WLYYEAGQRF LEVQYLTGGL IEPDAPGRVP LDEALQRGMV
DARTAQKLRD VGAYSKYLTC PKTKLKISYK DALDRSMVEE GTGLRLLEAA AQSSKGYYSP
YSVSGSGSTA GSRSGSRTGS RAGSRRGSFD ATGSGFSMTF SSSSYSSSGY GRRYASGPAP
SLGGPESAAA
//
