ID   A0A2Y9JF24_ENHLU        Unreviewed;       894 AA.
AC   A0A2Y9JF24;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Sorting nexin-14 isoform X12 {ECO:0000313|RefSeq:XP_022359191.1};
GN   Name=LOC111147461 {ECO:0000313|RefSeq:XP_022359191.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022359191.1};
RN   [1] {ECO:0000313|RefSeq:XP_022359191.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022359191.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   RefSeq; XP_022359191.1; XM_022503483.1.
DR   AlphaFoldDB; A0A2Y9JF24; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          78..252
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          284..416
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          518..638
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   894 AA;  103980 MW;  2A46E155B7DCD7D8 CRC64;
     MIFWSFVAGV VTFYCSLGPD SLLPNIFFTI KYKPKQLGLQ ELFPQGRSCA VCGKVKCKRH
     RPSLLLENYQ PWLDLKISSK VDASLSEVLE LVLENFVYPW YRDVTDDESF VDELRITLRF
     FASVLIRRIH KVDIPSIITK KLLKAAMKHI EVIVKASQKV ENTEFLQQAA LEEYGPELHV
     ALRSRRDELH YLRKLTELLF PYILPPKATD CRSLTLLLRE ILSGSVFLPS LDFLADPDTV
     NHLLIIFIDD SPPEKATELP SPLVPFLQKF AEPRNKKPSV LKLELKHIRE QQDLLFRFMN
     FLKQEGAVHV LQICLTVEEF NDRILRPELS NDEMLSLHEE LQKIYKTYCL DESIDKIRFD
     PFIVEEIQKI AEGPYIDVVK LQTMRCLFEA YEHVLSLLEN VFTPMFCHSD EYFRQLLRGA
     ESPTRNSKLN RGSLSLDDFR STQKRGESFG ISRIGSKIKG VFKSTTMEGA MLPNYGLAEG
     EDDFIEEGIV VMEDDSPVEA VSTPNTPRNL AAWKISIPYV DFFEDPSSER KEKKERIPVF
     CIDVERNDRR AVGHEPEHWS VYRRYLEFYV LESKLTEFHG TFPDAQLPSK RIIGPKNYEF
     LKSKREEFQE YLQKLLQHPE LSNSQLLADF LSPNGGETQF LDKILPDVNL GKIIKSVPGK
     LMKEKGQHLE PFIMNFINSC ESPKPKPSKP ELTILSPTSE NNKKLFSDLF KNNANRAENT
     ERKQNQNYFM EMMTVEGVYD YLMYVGRVVF QVPDWLHHLL MGTRILFKNT LEMYTDYYLH
     CKLEQLFQEH RLVSLITLLR DAVFCENTEP RSLQDKQKRA KQTFEEMMNY IPDLIVKCIG
     EEAKYESIRL LFDGLQQPVL NKQLTYVLLD IVIQELFPEL SKVQKEVTSV TSWM
//