ID   A0A2Y9JG85_ENHLU        Unreviewed;      1067 AA.
AC   A0A2Y9JG85;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Disheveled-associated activator of morphogenesis 2 isoform X3 {ECO:0000313|RefSeq:XP_022359616.1};
GN   Name=LOC111147685 {ECO:0000313|RefSeq:XP_022359616.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022359616.1};
RN   [1] {ECO:0000313|RefSeq:XP_022359616.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022359616.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022359616.1; XM_022503908.1.
DR   AlphaFoldDB; A0A2Y9JG85; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014767; DAD_dom.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR010472; FH3_dom.
DR   InterPro; IPR014768; GBD/FH3_dom.
DR   InterPro; IPR010473; GTPase-bd.
DR   PANTHER; PTHR45725:SF7; DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 2; 1.
DR   PANTHER; PTHR45725; FORMIN HOMOLOGY 2 FAMILY MEMBER; 1.
DR   Pfam; PF06367; Drf_FH3; 1.
DR   Pfam; PF06371; Drf_GBD; 1.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM01139; Drf_FH3; 1.
DR   SMART; SM01140; Drf_GBD; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51231; DAD; 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51232; GBD_FH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          40..416
FT                   /note="GBD/FH3"
FT                   /evidence="ECO:0000259|PROSITE:PS51232"
FT   DOMAIN          595..994
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   DOMAIN          1016..1047
FT                   /note="DAD"
FT                   /evidence="ECO:0000259|PROSITE:PS51231"
FT   REGION          516..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          434..510
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          688..715
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          965..1001
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1067 AA;  123291 MW;  5CF64B73B03E70CD CRC64;
     MAPRKRSRHG LGFLCCFGGS SLPEINLRDN HPLQYMEFSS PIPNPEELNV RFAELVDELD
     LTDKNREAVF ALPPEKKWQI YCSKKKEQED PNKLATSWPD YYIDRINSMA AMQSLYAIDE
     EETEMRNQIV EDLKTALRTQ PMRFVTRFIE LEGLTCLLNF LRSMDHATCE SRIHTSLIGC
     IKALMNNSQG RAHVLAQPEA ISTIAQSLRT ENSKTKVAVL EILGAVCLVP GGHKKVLQAM
     LHYQVYAAER TRFQTLLNEL DRSLGRYRDE VNLKTAIMSF INAVLNAGAG EDNLEFRLHL
     RYEFLMLGIQ PVIDKLRQHE NAILDKHLDF FEMVRNEDDL ELARRFDMVH IDTKSASQMF
     ELIHKKLKHT EAYPCLLSVL HHCLQMPYKR NGGYFQQWQL LDRILQQIVL QDERGVDPDL
     APLENFNVKN IVNMLINENE VKQWRDQAEK FRKEHMELVS KLERKERECE TKTLEKEEMM
     RTLNKMKDKL ARESQELRQA RGQVAELVAQ LSEISVRPVS SPPPPGGPLT LSSSMTTNDL
     PPPPPPLPFA CCPPPPPPPL PPGGPPTPPG APPCFSMGLP LPPDPCPSSD IPLRKKCVPQ
     PSHPLKSFNW VKLNEARVPG TVWNEIDDMQ VFRILDLEDF EKMFSAYQRH QKELGSTEDI
     YLASRKVKEL SVIDGRRAQN CIILLSKLKL SNEEIRQAIL KMDEQEDLAK DMLEQLLKFI
     PEKSDIDLLE EHKHEIERMA RADRFLYEMS RIDHYQQRLQ ALFFKKKFQE RLAEAKPKVE
     AILLASRELI RSKRLRQMLE VVLAIGNFMN KGQRGGAYGF RVASLNKIAD TKSSIDRNIS
     LLHYLIMILE KHFPDILNMP SELQHLPEAA KVNLAELEKE VGNLRRGLRA VEVELEYQKR
     QAREPNDKFV PVMSDFITVS SFSFSELEDQ LNEARDKFSK ALMHFGEQDS KMQPDEFFGI
     FDTFLQAFSE ARQDLEAMRR RKEEEERRTR MEAMLKEQRE RERWQRQRKA HTGSALEEGG
     EFDDLVSALR SGEVFDKDLC KLKRSRKRSG SQALDVTRER AISRLNY
//