ID   A0A2Y9JH29_ENHLU        Unreviewed;      1731 AA.
AC   A0A2Y9JH29;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=5'-3' exoribonuclease 1 isoform X2 {ECO:0000313|RefSeq:XP_022359881.1};
GN   Name=LOC111147901 {ECO:0000313|RefSeq:XP_022359881.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022359881.1};
RN   [1] {ECO:0000313|RefSeq:XP_022359881.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022359881.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022359881.1; XM_022504173.1.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0008409; F:5'-3' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR   CDD; cd18673; PIN_XRN1-2-like; 1.
DR   Gene3D; 1.25.40.1050; -; 1.
DR   Gene3D; 2.170.260.40; -; 1.
DR   Gene3D; 2.30.30.750; -; 1.
DR   Gene3D; 3.40.50.12390; -; 1.
DR   InterPro; IPR027073; 5_3_exoribonuclease.
DR   InterPro; IPR016494; 5_3_exoribonuclease_1.
DR   InterPro; IPR041385; SH3_12.
DR   InterPro; IPR040992; XRN1_D1.
DR   InterPro; IPR047007; XRN1_D1_sf.
DR   InterPro; IPR041106; XRN1_D2_D3.
DR   InterPro; IPR041412; Xrn1_helical.
DR   InterPro; IPR004859; Xrn1_N.
DR   InterPro; IPR047008; XRN1_SH3_sf.
DR   PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR   PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR   Pfam; PF18129; SH3_12; 1.
DR   Pfam; PF18332; XRN1_D1; 1.
DR   Pfam; PF18334; XRN1_D2_D3; 1.
DR   Pfam; PF17846; XRN_M; 1.
DR   Pfam; PF03159; XRN_N; 1.
DR   PIRSF; PIRSF006743; Exonuclease_Xnr1; 2.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
PE   4: Predicted;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          1..227
FT                   /note="Xrn1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03159"
FT   DOMAIN          272..597
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   DOMAIN          654..844
FT                   /note="5'-3' exoribonuclease 1 D1"
FT                   /evidence="ECO:0000259|Pfam:PF18332"
FT   DOMAIN          850..1075
FT                   /note="Exoribonuclease Xrn1 D2/D3"
FT                   /evidence="ECO:0000259|Pfam:PF18334"
FT   DOMAIN          1102..1171
FT                   /note="5'-3' exoribonuclease 1 SH3-like"
FT                   /evidence="ECO:0000259|Pfam:PF18129"
FT   REGION          1367..1386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1411..1442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1642..1731
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1418..1442
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1648..1718
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1731 AA;  196873 MW;  C3AFAF4241676CCD CRC64;
     MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI
     FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKALEKGE
     TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK
     IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA
     PEETTFHLLH LSLMREYIDY EFSVLKDKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL
     HINHDALPLL YGTYITILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH FSEVFVDLKW
     FESKVGNKYL NEAAGVAAEE AKNYKEKKKT KGQENAICWA ALDKSGEEVV TSKDNLEDET
     EDDDLFETEF RQYKRTYYMT KMGVDVVSDD FLADQAACYV QAIQWILHYY YHGVQSWSWY
     YPYHYAPFLS DIRNISTLKI HFELGKPFKP FEQLLAVLPA ASKNLLPTCY QHLMTSEDSP
     IIEYYPPDFK TDLNGKQQEW EAVVLIPFID EKRLLEAMET CNHSLKKEER KRNQHSECLM
     CWYDRDTEFT YPSPWPEKFP AIEHCCTRYK IISLDAWRVD ISKNKITRVD QKALYFCGFP
     TLKHIKHKFF LKKSGVQVFQ QSSRGENMML EILVNAESDE FCVENIASSV LGKSVFVNWP
     HLEEARVVGI SDGETKFYLE EPPGTQKLYL GRTAPPSKVV HLGDKEQSNW TKEVQGISEY
     YLRRKGIIIN ETSAVVYAQL LTGRKYQINQ NGEVHLEKQW SKQVLPFVYQ TIVKDIRAFD
     SRFSKIKTLD DLFPPRSTVF MLGTPYYGCT GEVQDSGDVI TEGRIRVIFS IPCEPNLDAL
     IQNQHKYSIK YNPGYVLASR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK ANVGLNLKFN
     KKNEEVPGYT KKVGSEWMYS SAAEQLLAEY LERAPELFSY IAKNSQEDVF YEDDIWPGEN
     ENGAEKVQEI ITWLKGHPVS TLSRSSCDLQ ILDAAIVEKI EEEVEKCKQR KNNKKVRVTV
     KPHLLYRPLE QQHGVIPDRD AEFRLFDRVV NVREYFSVPV GLRGTIIGIK GANREADVLF
     EVLFDEEFPG GLTIRCSPGR GYRLPTSALV NLTHGSRSET GNQKLTAIVK PQPAVNHYSS
     NSSISSGHLG GLNHSPQSLF VPTQVPTKDD DEFCNIWQSL QGSGKVQHFQ PTLQEKVTVL
     PQEISQVTQH HKSGFTDNSV KCQQRKHEAH RKFKEECKSP KTETRLQKMS NKQMFGGPAK
     CNIKLLKRNE SAEVSENQKV VTGYPNAIDK PNPRIENFLA SLNISKENEV QSSHHEEPPS
     EELLSPQSFA MKGTRMLKEI LKIDGSDAVD HKNETKQFGN EVNVSSNRRD EYGPSSQAKQ
     NKKLTSYMNK PHSTSEYHNV QSMDHVCWPA PSHIPPVSTP VTELSRICSL IGMPQPDFSF
     LRTPQTMTVC QVKLSNGLLV HGPQCHSENE AKEKAALFAL QQLGSLGVNF PLPPPIFPNY
     PPAVPPGTIP PVFPQPTANI MPSSSHLFGS MPWGPPVPVP GKPFHHPSYS GTMPMAGGMP
     GGVHNQFIPL QVTKKRVANK KNLESKEAQS SHATPLQTSQ PGSSSVTKVI PQESSSASLK
     SSQNTQPASS FQVEAASQGH SMSHHKSTPS SSSRRKSRKL AVNFGVSKPS E
//