ID A0A2Y9JHA4_ENHLU Unreviewed; 592 AA.
AC A0A2Y9JHA4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=PHD finger protein 19 isoform X1 {ECO:0000313|RefSeq:XP_022357170.1};
GN Name=LOC111146081 {ECO:0000313|RefSeq:XP_022357170.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022357170.1};
RN [1] {ECO:0000313|RefSeq:XP_022357170.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022357170.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Polycomblike family.
CC {ECO:0000256|ARBA:ARBA00008084}.
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DR RefSeq; XP_022357170.1; XM_022501462.1.
DR AlphaFoldDB; A0A2Y9JHA4; -.
DR STRING; 391180.A0A2Y9JHA4; -.
DR KEGG; elk:111146081; -.
DR OrthoDB; 5483634at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035064; F:methylated histone binding; IEA:UniProt.
DR CDD; cd15579; PHD1_PHF19; 1.
DR CDD; cd15581; PHD2_PHF19; 1.
DR CDD; cd20451; Tudor_PHF19; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.90.980.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR040477; KDM4-like_Tudor.
DR InterPro; IPR025894; Mtf2_C_dom.
DR InterPro; IPR042017; PHF19_PHD2.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047400; Tudor_PHF19.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12628:SF6; PHD FINGER PROTEIN 19; 1.
DR PANTHER; PTHR12628; POLYCOMB-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF14061; Mtf2_C; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF18104; Tudor_2; 1.
DR SMART; SM00249; PHD; 2.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 50..107
FT /note="Tudor"
FT /evidence="ECO:0000259|SMART:SM00333"
FT DOMAIN 110..161
FT /note="Zinc finger PHD-type"
FT /evidence="ECO:0000259|SMART:SM00249"
FT DOMAIN 209..259
FT /note="Zinc finger PHD-type"
FT /evidence="ECO:0000259|SMART:SM00249"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 592 AA; 66449 MW; 279CCC14642A7256 CRC64;
MPGAGTGCQG KLMENRSLDP GTRDSYGATT HLPNKGALAK AKNNFKDLMS KLTEGQYVLC
RWTDGLYYLG KIKRVSSSKQ SCLVTFEDNS KYWVLWKDIQ HAGVPGEEPK CNICLGKTSG
PLNEILICGK CGLGYHQQCH IPRAGSADRP LLTPWFCRRC IFALAVRKGG ALKKGAIART
LQAVKMVLSY QPEELEWDSP HRTNQQQCYC YCGGPGEWYL RMLQCHRCRQ WFHEACTQCL
NEPMMFGDRF YLFFCSVCNQ GPEYIERLPL RWVDVVHLAL YNLGVQSKKK YFDFEEILAF
VNHHWELLQL GKLTSTPVTD RGPHLLNALN SYKSRFLCGK EIKKKKCIFR LRIRVPPNPP
GKLLPDKGLV PTESGGASEL RKRGKSKPGL LPHEFQQQKR RVYRRKRSKF LLEDAIPSSD
FTSAWSTNHH LASIFDFSLD EIQSLKSASS GQTFFSDVDS TDAASTSGSA STSLSYDSRR
TVGSRKRKLG AKAYLPLRAK RRAAELGGRC PSDSSAEAAS GPERLDEGID SHTFESISED
DSSLSHLKSS ITNYFGAAGR LACGEKYQVL ARRVTPEGKV QYLVEWEGTT PY
//
