ID A0A2Y9JHE1_ENHLU Unreviewed; 2854 AA.
AC A0A2Y9JHE1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Adenomatous polyposis coli protein isoform X3 {ECO:0000313|RefSeq:XP_022360448.1};
GN Name=LOC111148270 {ECO:0000313|RefSeq:XP_022360448.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022360448.1};
RN [1] {ECO:0000313|RefSeq:XP_022360448.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022360448.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR RefSeq; XP_022360448.1; XM_022504740.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.450; Helix hairpin bin; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009240; APC_15aa_rpt.
DR InterPro; IPR009234; APC_basic_dom.
DR InterPro; IPR026831; APC_dom.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR009232; EB1-bd.
DR InterPro; IPR009224; SAMP.
DR PANTHER; PTHR12607:SF11; ADENOMATOUS POLYPOSIS COLI PROTEIN; 1.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR Pfam; PF05972; APC_15aa; 4.
DR Pfam; PF05956; APC_basic; 1.
DR Pfam; PF05923; APC_r; 7.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF16634; APC_u13; 1.
DR Pfam; PF16635; APC_u14; 1.
DR Pfam; PF16636; APC_u15; 1.
DR Pfam; PF16630; APC_u5; 1.
DR Pfam; PF16633; APC_u9; 1.
DR Pfam; PF00514; Arm; 3.
DR Pfam; PF16629; Arm_APC_u3; 1.
DR Pfam; PF05937; EB1_binding; 1.
DR Pfam; PF05924; SAMP; 3.
DR Pfam; PF11414; Suppressor_APC; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF82931; Tumor suppressor gene product Apc; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 670..712
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 2235..2586
FT /note="Adenomatous polyposis coli protein basic"
FT /evidence="ECO:0000259|Pfam:PF05956"
FT DOMAIN 2681..2854
FT /note="EB-1 binding"
FT /evidence="ECO:0000259|Pfam:PF05937"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1198..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1319..1386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1671..1858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1887..1954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1977..2022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2054..2082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2159..2649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2676..2725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2743..2854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 144..178
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 19..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..867
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1319..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1367..1384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1443..1457
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1554..1572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1690..1710
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1759..1773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1797..1842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1887..1905
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1906..1948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2181..2202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2211..2236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2245..2260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2269..2437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2472..2518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2530..2544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2568..2591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2592..2607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2628..2649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2680..2697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2708..2722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2748..2824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2834..2854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2854 AA; 312280 MW; C9215955A7E69A70 CRC64;
MYASLGSGPV GALPASAPPS TLGSWSSGSG SGCVPQERKR PGGVRTSGRG ASVWQEVLKQ
LQGSIEDEAM ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE GSVSSRSGEC
SPVPMGSFPR RGFVNGSREN TGYLEELEKE RSLLLADLDK EEKEKDWYYA QLQNLTKRID
SLPLTENFSL QTDMTRRQLE YEARQIRVAM EEQLGTCQDM EKRAQRRVTR IQQIEKDILR
IRQLLQSQAT EAERSSQNKH EAGSHEAERQ NEGQGVAEIN MATSGSGQGS TTRMDHETAS
VLSSSSTHSA PRRLTSHLGT KVEMVYSLLS MLGTHDKDDM SRTLLAMSSS QDSCISMRQS
GCLPLLIQLL HGNDKDSVLL GNSRGSKEAR ARASAALHNI IHSQPDDKRG RREIRVLHLL
EQIRAYCETC WEWQEAHEQG MDQDKNPMPA PVEHQICPAV CVLMKLSFDE EHRHAMNELG
GLQAIAELLQ VDCEMYGLTN DHYSITLRRY AGMALTNLTF GDVANKATLC SMKGCMRALV
AQLKSESEDL QQVIASVLRN LSWRADVNSK KTLREVGSVK ALMECALEVK KESTLKSVLS
ALWNLSAHCT ENKADICAVD GALAFLVGTL TYRSQANTLA IIESGGGILR NVSSLIATNE
DHRQILRENN CLQTLLQHLK SHSLTIVSNA CGTLWNLSAR NPKDQEALWD MGAVSMLKNL
IHSKHKMIAM GSAAALRNLM ANRPAKYKDA NIMSPGSSLP SLHVRKQKAL EAELDAQHLS
ETFDNIDNLS PKASHRNKQR HKQSLYNDYV FDTNRHDDNR SDNFNTGNMT VLSPYLNTTV
LPSSSSSRGS LDSSRSEKDR SLERERGISL GNYHPATENS GTSSKRGLQI STTAAQIAKV
MEEVSAIHTS QEDRSSGSTT ELHCGTDERN ALRRSSTAHT HANTYNFSKS EGSNRTCPVT
YANLEYKRSS NDSLNSVSSS DGYGKRGQMK PSIESYSEDD ESKFCSYGQY PADLAHKIHS
ANHMDDNDGE LDTPINYSLK YSDEQLNSGR QSPSQNERWA RPKHIIEDEI KQSEQRQSRS
QSTTYPVYTE STDDKHLKFQ PHFGQQECVS PYRSRGASGS ETNRVGSNHG INQNVNQSLC
QEDDYEDDKP TNYSERYSEG EQHEEEERPT NYSIKYNEEK HHVDQPIDYS LKYATDISSS
QKPPFSFSKN SSGQSTKTEH LSSSSENTST PSANAKRQNQ HHPSSAQSRN GQTPKATSCK
VPSINQETIQ TYCVEDTPIC FSRCSSLSSL SSAEDEIGCD QATQETDSAN TLQIAEIKEN
SGTRTTEDSV SEVPTVSQHI RTKSSRLQAS GLSAESTRHK AVEFSSGAKS PSKSGAQTPK
SPPEHYVQET PLMFSRCTSV SSLDSFESRS IASSVQSEPC SGMVSGIISP SDLPDSPGQT
MPPSRSKTPP PPPQTVQTKR EVPKNKAPAV EKRESGPKQA AVNAAVQRVQ VLPDADTLLH
FATESTPDGF SCSSSLSALS LDEPFIQKDV ELRIMPPVQE NDNGNETESE QPEEANENQE
KETEKPTDSE KDLLDDSDDD DIEILEECII SAMPTKSSRK AKKPAQTASK LPPPVARKPS
QLPVYKLLPS QNRLQAQKHV SFTPGDDMPR VYCVEGTPIN FSTATSLSDL TIESPPNELA
AGEGVRPGAQ SSEFEKRDTI PTEGRSTDEA QRGKTPSVTI PELDDSKTEE GDILAECINS
AMPKGKSHKP FRVKKIMDQV QQASMSSSGA NKNQLDGKKK KPTSPVKPIP QNTEYRTRVR
KNADSKNNLN AERTFSDNKD SKKQNLKNNS KDFNDKLPNN EDRVRGSFTF DSPHHYTPIE
GTPYCFSRND SLSSLDFDDD DVDLSREKAE LRKGKENKES EAKVTSHTEL TTNQQSANKT
QAVTKHPINR GQSKSLLQKQ STFPQSSKDI PDRGAATDEK LQNFAIENTP VCFSRNSSLS
SLSDIDQENN NNKENEPIKE TEPPNSQGEP SKPQASGYAP KSFHVEDTPV CFSRNSSLSS
LSIDSEDDLL QECISSAMPK KKKPSRLKGD NEKHSPRNMS GILAEDLTLD LKDIQRPDSE
HGLSPDSENF DWKAIQEGAN SIVSSLHQAA AAACLSRQAS SDSDSILSLK SGISLGSPFH
LTPDQEEKPF TSNKGPRILK PGEKSTLETK KIESENKGIK GGKKVYRSLL TGKVRSNSEI
SNQMKQSLQA NMPSISRGRT MIHIPGVRNS SSSTSPVSKK GPPLKTPASK SPSEGQTATT
SPRGPKPSVK SELSPVTRQT SQPAVANKGP SRSGSRDSTP SRPAQQPLSR PMQSPGRNSI
SPGRNGISPP NKLSQLPRTS SPSTASTKSS GSGKMSYTSP GRQMSQQNLT KQTGLSKNGS
SIPRSESASK GLNQMNNSNG SNKKVELSRM SSTKSSGSES DRSERPVLVR QSTFIKEAPS
PTLRRKLEES ASFESLSPSS RPDSPTRSQA QTPVLSPSLP DMSLSTHSSV QSGGWRKLPP
NLSPTIEYND GRPVKRHDIA RSHSESPSRL PINRSGTWKR EHSKHSSSLP RVSTWRRTGS
SSSILSASSE SSEKAKSEDE KHVNSISGAK QTKENQVSTK GTWRKIKESE ISPTNSTSQT
TSSGAANGAE SKTLIYQMAP AVSKTEDVWV RIEDCPINNP RSGRSPTGNT PPVIDTVSEK
GNPNAKDAKD NQGKQNVGNG SAPVRTMGLE NRLNSFIQVD APDQKGTEAK PGQSNPVPAS
ETNESSVAER TPFSSSSSSK HSSPSGTVAA RVTPFNYNPS PRKSSADSTS ARPSQIPTPV
NNNTKKRDSK TDSTESSGTQ SPKRHSGSYL VTSV
//
