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Database: UniProt
Entry: A0A2Y9JJ46_ENHLU
LinkDB: A0A2Y9JJ46_ENHLU
Original site: A0A2Y9JJ46_ENHLU 
ID   A0A2Y9JJ46_ENHLU        Unreviewed;       903 AA.
AC   A0A2Y9JJ46;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Chloride channel protein 2 {ECO:0000256|ARBA:ARBA00017377};
GN   Name=LOC111148398 {ECO:0000313|RefSeq:XP_022360626.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022360626.1};
RN   [1] {ECO:0000313|RefSeq:XP_022360626.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022360626.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClC-
CC       2/CLCN2 subfamily. {ECO:0000256|ARBA:ARBA00005423}.
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DR   RefSeq; XP_022360626.1; XM_022504918.1.
DR   AlphaFoldDB; A0A2Y9JJ46; -.
DR   STRING; 391180.A0A2Y9JJ46; -.
DR   KEGG; elk:111148398; -.
DR   OrthoDB; 1194at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR   CDD; cd03683; ClC_1_like; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 2.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002244; Cl-channel-2.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR   PANTHER; PTHR45720:SF6; CHLORIDE CHANNEL PROTEIN 2; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01113; CLCHANNEL2.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   TRANSMEM        94..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        137..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        211..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        242..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        324..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        367..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        434..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        462..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        532..551
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          649..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          861..903
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        862..876
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   903 AA;  98870 MW;  20C8DC26C4393ED8 CRC64;
     MAAAGAAAAA EGMEPRALQY EQTLMYGRYT QDLGAFAKEE AARIRLGGPE TWRGPPSSRA
     PPELLEYGQS RCAQCRICSV RCHKFLVSRV GEDWIFLVLL GLLMALVSWA MDYAIAACLQ
     AQQWMSRGLN TSLFLQYLAW VTYPIVLITF SAGFTQILAP QAVGSGIPEM KTILRGVVLK
     EYLTLKTFVA KVIGLTCALG SGMPLGKEGP FVHIASMCAA LLSKFLSLFG GIYENESRNT
     EMLAAACAVG VGCCFAAPIG GVLFSIEVTS TFFAVRNYWR GFFAATFSAF IFRVLAVWNR
     DEETITALFK TRFRLDFPFD LQELPAFAVI GIASGFGGAL FVYLNRKIVQ VMRKQKTINR
     FLMKKRLLFP ALVTLLISTL TFPPGFGQFM AGQLSQKETL VTLFDNRTWV RQGLVEDLEP
     PGTSQAWSPP RANVFLTLVV FILMKFWMSA LATTIPVPCG AFMPVFVIGA AFGRLVGESM
     AAWFPDGIHT DGSTYRIVPG GYAVVGAAAL AGAVTHTVST AVIVFELTGQ IAHILPVMIA
     VILANAVAQS LQPSLYDSII RIKKLPYLPE LGWGRHQQYR MRVEDIMVRD VPYVALSCTF
     RDLRLALHRT KGRMLALVES PESMILLGSI ERSQVVALLA AQLSPARRRQ YAQERRAAQT
     SPPPDQESPP SPEASVRFQV NTEDSGFPAA RGDTHKPLKP ALKRGPSNTM NLGESPTGNM
     EQAGIALRSL FCGSPPPEAA SELEKSESGD KRKLKRVRIS LASDSDLEGE MSPEEILEWE
     EQKLDEPVNF SDCKIDPAPF QLVERTSLHK THTIFSLLGV DHAYVTSIGR LIGIVTLKEL
     RKAIEGSVTA QGVKVRPPLA SFRDSATSSS DTETTEVHAL WGPHSHHGLP REGSPSDSDD
     KCQ
//
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