ID A0A2Y9JKU8_ENHLU Unreviewed; 1300 AA.
AC A0A2Y9JKU8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Limbin {ECO:0000313|RefSeq:XP_022361708.1};
GN Name=LOC111149087 {ECO:0000313|RefSeq:XP_022361708.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022361708.1};
RN [1] {ECO:0000313|RefSeq:XP_022361708.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022361708.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_022361708.1; XM_022506000.1.
DR STRING; 391180.A0A2Y9JKU8; -.
DR KEGG; elk:111149087; -.
DR OrthoDB; 4261679at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1300
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015878800"
FT TRANSMEM 288..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 29..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 454..481
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1300 AA; 146829 MW; DD711FF644951003 CRC64;
MGSAGAAGRA TSVLTWSLLA AALALPAGPG GRRWHPAGPD LLRRPLGRQP LLDPPAAPGA
GPERTTQDLP HLIWPSAESS GFKTAVGAWF GRKSSVRSEV FNPLPTLAPS RGPRTQSVLA
FTPSWPKKTL FKRESPVTHR LFRDISRDVP GTAEDGVIFQ KCAVVSGQSE PQTAQVRLLI
DNTRTPAATN LSDLLLFDNI TGLSVRGSTG NQTMPGFQAF RKKFLQVGDS FLVSYTASIK
AGEVGSGEVL MLPAQLTFQS SAQNRTQLKA LFTITVEEKI KVIPNHGLHA AGFFAASIVS
FVLTWVTLFF MARYQCLKGS LLTRHGVQHH ESKLEYSQFT SPDDVNEDLA LNDQMIDILS
SEDPGSMLQA LEELEIATLN RADSDLEACR TQISRDIIAL LLKNLTSSGH LSPQVERRMG
AVFKKQFLLL EKEIQEEYDR KMVALTAECD LEMRKKTESQ YQREMAAMEE AEELLKRVSE
RSALECSGLL RTLHGLEQAH LRRSLALQQE EDFVKAHRQL AVFQRNELHN IFFTQIKSAI
FQGELKPEAA RMLLQDYADI QEKLEELMDF LQASKRYHLS KRFGHREYLV QNMQSSETRV
QGLLSAADAQ LTLFIQKHER AGYLDEEQTE ALLGRAQTEV FSIRQKLDND LKQEKKKLHQ
KLILKRRREM LQKHKEQRKE QLSLGEALRA AEDAGQYLGR WGSLLAEQGA VLETLQERLD
QAALEELRAL TLSLSEKATE ELRRLQTSGM TQELLKRGVP WLFLQQILEE HSRELVARAQ
QLEGEERDRD QEGVQSVRQR LKDDALEAST EEQAELRRWE HLIFMKLCSS AFSLSEDELL
RLRQEVHGCF AQMDRSLALP KIRARALLQQ FQTAWREAEF RRLDQALAAP ELQQQSKARK
SRSKSKSKID LLRKCIEDKI QLFEEQAPED LVEKVRGELL RERVQQLEAQ EARFAESLVS
LQFQKAARMA TTLWAYTALL SIQDLLLEEL SESETLTKLA CEQILGSHSP ELQELERKLE
DKLAQQEAAQ IQRALASQQQ WAGDGPGLLG MPEDTDSGRQ VSAVLQQALS QARKLLERQQ
QSWREERDHS VVLEDLLENV EFDTFATLYS QELRLASYLS RLAMVPGGTL RRLLSVALPT
ASQSELLAAL DPSSQKHPDH MVENNGGGEP ADLGRRRKHQ GWWQALESRL RGELISRGLE
KMLWARERKE SILKKTCPPL KERVIFPGKG SWPHLSLESI GELAAIPIIG AETIDLLNTG
EKLFIFRNPK EPEISLHVPP KRKKKNFLNA KKATWALGMD
//