ID A0A2Y9JKY5_ENHLU Unreviewed; 258 AA.
AC A0A2Y9JKY5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=LOC111149117 {ECO:0000313|RefSeq:XP_022361748.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022361748.1};
RN [1] {ECO:0000313|RefSeq:XP_022361748.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022361748.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ADP-ribosyl cyclase family.
CC {ECO:0000256|ARBA:ARBA00005406}.
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DR RefSeq; XP_022361748.1; XM_022506040.1.
DR AlphaFoldDB; A0A2Y9JKY5; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd04759; Rib_hydrolase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR003193; ADP-ribosyl_cyclase.
DR PANTHER; PTHR10912; ADP-RIBOSYL CYCLASE; 1.
DR PANTHER; PTHR10912:SF4; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 2; 1.
DR Pfam; PF02267; Rib_hydrolayse; 1.
DR SUPFAM; SSF52309; N-(deoxy)ribosyltransferase-like; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801,
KW ECO:0000313|RefSeq:XP_022361748.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 258 AA; 29007 MW; 772E2543AEEE3D3F CRC64;
MESKGGRNCT AIWEAFKVVL VKDPCSVLPS DYDRFIDLSR HSIPRDKSLF WENNHLLVTS
YSENGLRFLP LCSVLYGRIG DFLSWCRQEN ASGLDYQSCP TSEDCENNAV DSFWKRASMQ
YARESSGVIS VMLNGSEPSG AYPVKGFFAD FEIPYFQKDK ITRIEIWVMH EIGKPKVESC
GEGTVKILEE RLKKMGFQYS CINDHLPVKL LKCVDHSTHP DCVLNSAAAS REIPPLWAEH
GASHIVPLLV ALASAVHM
//
