ID A0A2Y9JLN3_ENHLU Unreviewed; 997 AA.
AC A0A2Y9JLN3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ubiquitin-like modifier-activating enzyme 6 isoform X2 {ECO:0000313|RefSeq:XP_022361486.1};
GN Name=LOC111148946 {ECO:0000313|RefSeq:XP_022361486.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022361486.1};
RN [1] {ECO:0000313|RefSeq:XP_022361486.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022361486.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673}.
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DR RefSeq; XP_022361486.1; XM_022505778.1.
DR AlphaFoldDB; A0A2Y9JLN3; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd01491; Ube1_repeat1; 1.
DR CDD; cd01490; Ube1_repeat2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR Gene3D; 3.10.290.60; Ubiquitin-activating enzyme E1, UFD domain; 1.
DR InterPro; IPR032420; E1_4HB.
DR InterPro; IPR032418; E1_FCCH.
DR InterPro; IPR042302; E1_FCCH_sf.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR018965; Ub-activating_enz_E1_C.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR038252; UBA_E1_C_sf.
DR InterPro; IPR019572; UBA_E1_SCCH.
DR InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR018075; UBQ-activ_enz_E1.
DR InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR NCBIfam; TIGR01408; Ube1; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF186; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6; 1.
DR Pfam; PF16191; E1_4HB; 1.
DR Pfam; PF16190; E1_FCCH; 1.
DR Pfam; PF09358; E1_UFD; 1.
DR Pfam; PF00899; ThiF; 2.
DR Pfam; PF10585; UBA_E1_SCCH; 1.
DR PRINTS; PR01849; UBIQUITINACT.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 866..988
FT /note="Ubiquitin-activating enzyme E1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00985"
SQ SEQUENCE 997 AA; 112135 MW; 0320E779086F75F7 CRC64;
MQKMAKSRVF LSGMGGLGLE IAKNLVLAGI KALTIHDTEK CQMWDLGTNF FLCEDDVVNR
RNRAEAVLQH IAELNPYVHV TSSSVPLDET TDLSFLDKYQ CVVLTEIKLP VQKKINNFCH
SHCPPIKFIS ADMHGVWSRL FCDFGDEFEV SDTTGEEPKE IFISNITQAN PGIVTCLENH
PHKLETGQFV TFREVNGMMS LNGSTQQITV VSPFSFSIGD TTELEPYLHG GIAVQIKTPK
TFCFEPLETQ IKHPKCLIAD FSNPEAPLEI HTAMLALDQF QENYNRKPNI GCQKDSEELL
KLATSISETL EEKPEVNADI VHWLSWTAQG FLPPLAAAVG GVASQEVLKA VTGKFSPLCQ
WLYIEAADIV ESLGKPEREQ FLPRGDRYDA LRACIGDTLC QKLQKLNIFL VGCGAIGCEM
LKNFALLGVG TGKEKGMVTV TDPDLIEKSN LNRQFLFRPH HIQKPKSYTA ADATLKINPQ
LKIDAHLNKV CPATEAIYND EFYTKQDIII TALDNVEARR YVDSRCLANL RPLLDSGTMG
TKGHTEVIVP HLTESYNSHR DPPEEEIPFC TLKSFPAAIE HTIQWARDKF ESSFSHKPSL
FNKFWQTYSS AEEVLQKIQT GHSLEGCFQV IKLLSRRPRN WSQCVELARL KFEKYFNHKA
LQLLHCFPLD TRLKDGSLFW QSPKRPPSPI KFDLNEPLHF SFLLNAAKLY AAVYCIPLTE
EDLSADALLN ILSEVKIQEF KPSNKVVQTD ETARKPEHVP ISSEDERNAV FQLEKAISSN
KATSSDLQMA VLSFEKDDDR NGHVDFITAA SNLRAKMYSI EPADRFKTKR IAGKIIPAIA
TSTAAVSGLV ALEMIKVAGD YPFEAYKNCF LNLAIPIIVF TETSEVKRTE IRNGISFTIW
DRWTIHGKED FTLLDFINVV KEKYGIEPTM VVQGVKMLYV PVMPGHAKRL KLTMHKLVKP
STEKKYVDLT VSFAPDTDGD EDLPGPPVRY YFSHDTD
//
