ID A0A2Y9JM19_ENHLU Unreviewed; 705 AA.
AC A0A2Y9JM19;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=LOC111148425 {ECO:0000313|RefSeq:XP_022360659.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022360659.1};
RN [1] {ECO:0000313|RefSeq:XP_022360659.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022360659.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
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DR RefSeq; XP_022360659.1; XM_022504951.1.
DR AlphaFoldDB; A0A2Y9JM19; -.
DR STRING; 391180.A0A2Y9JM19; -.
DR KEGG; elk:111148425; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF95; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 6A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 216..241
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 302..323
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 360..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 408..433
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 445..463
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 568..595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 602..623
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 654..679
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 484..539
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 78023 MW; A55A985784CF4DB6 CRC64;
MPDALAEVEP KAAQPQVAEN PLETEQAKRK KKPKLMKIFP TSLIKFHTFQ NKEKGQAGAT
SPITKKPKEN LEGPCGLGCI VISRCQRFNK LHCFLVFYGL LITSQGIVFG LKELSIDTFE
EGNHLKDVED LLLPLPYDIS SFLVAVFIAY YGGKGNIPRW VTFASFLVGF GSLLFAYPYF
TEGDFKANVD IEEDICQEMK TVQACRKTVP SFHVKYFVSF ILGQTVQGVA AMILYILGIV
FIDNSVAIHS AGIYIGIMEA SFVFGYSLSY GIAAPLLKGT KNRTSAISVE DSYDIQSWLQ
HWWIYFGMVS LIAWSTLIPL SCFPHSVQGT AKIKAEKLKQ PHPFGGQIKD KEFETSIKDL
FATIWVLLKN PILICLALAK ASGSFVFIGA SEYLPLYIEN QFSLTRSIAT KIAGFVLLPA
GGLGELLGGI IVSTLHMSCK ALMRFIMVTS AVSLMFFGFV IFINCAPVPL AGINEDYSGT
GQLGNLTAPC NSHCRCSSSF YSVICGRDNI GYFSPCFAGC TLFKTLNDGK AYYNCSCIQE
GLTTSDEQGD FIDARPGACN TKCYKLPLFI AFIFSTILFS VLSNTPCTLT ILRIVSDNQR
SLALGLTYVI LRIFATIPGP ILFKLARDSS CLFRETEHCK RKGNCWSYDK KKMAYLMVGI
CSVCKVFAIF FTAIAYCLYK YISKRDGDSL HIPVKSLKVK KKGKK
//
